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drugs in class
phenelzine (Nardil)
selegiline (Eldepryl)
properties/MOA
· Only used if other meds fail
· ↑ NE availability in synapsis
· MANY food interactions
→ tyramine
Inhibits MAO in nerve terminals
effects/adverse Rxn
· Orthostatic hypotension
· “Cheese reaction”
→ cheeses
→ cured meats/fish
→ figs
→ bananas
→ alcoholic beverages
→ herbs
contraindications
Contraindicated w/:
meperidine (Demerol)
fluoxetine (Prozac)
Alcohol
Foods w/tyramine
→ lethal
nursing info
· Avoid many foods
Rx’d after other medications ineffective