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Cardiac Output
Heart Rate × Stroke Volume
Stroke Volume
Amount of blood pumped per beat (SV = EDV - ESV)
End Diastolic Volume (EDV)
Amount of blood in ventricle before contraction (preload)
End Systolic Volume (ESV)
Amount of blood left in ventricle after contraction
Ejection Fraction (EF)
Percentage of blood ejected (SV / EDV)
Preload
Amount of stretch on the ventricle before contraction (related to EDV)
Afterload
Pressure the heart must overcome to eject blood
Contractility
Force of heart contraction
Frank-Starling Mechanism
More filling (EDV) leads to stronger contraction and higher SV
Heart Rate (HR)
Number of beats per minute
Cardiac Output (CO or Q)
Amount of blood pumped per minute
Resting Cardiac Output
~5 L/min
Pulse Pressure (PP)
Systolic BP - Diastolic BP
Mean Arterial Pressure (MAP)
DBP + 1/3(PP)
Rate Pressure Product (RPP)
HR × SBP (heart workload)
Systolic Blood Pressure (SBP)
Pressure during heart contraction
Diastolic Blood Pressure (DBP)
Pressure during heart relaxation
Effect of Exercise on SBP
Increases with intensity
Effect of Exercise on DBP
Stays same or slightly decreases
Fick Equation
VO2 = Q × a-vO2 difference
a-vO2 Difference
Amount of oxygen extracted by tissues
Effect of Exercise on HR
Increases linearly
Effect of Exercise on SV
Increases early, then plateaus
Effect of Exercise on CO
Increases with intensity
Effect of Exercise on a-vO2 diff
Increases with exercise
Cardiovascular Drift
HR increases and SV decreases during prolonged exercise
Cause of CV Drift
Dehydration and increased body temperature
Vasodilation
Widening of blood vessels
Vasoconstriction
Narrowing of blood vessels
Cause of Vasodilation in Muscle
Low O2, high CO2, low pH, nitric oxide
Skeletal Muscle Pump
Muscle contractions help return blood to heart
Respiratory Pump
Breathing helps move blood back to heart
Acute Response
Immediate change during exercise
Chronic Adaptation
Long-term change from training
Effect of Training on Resting HR
Decreases
Effect of Training on Stroke Volume
Increases
Effect of Training on Blood Volume
Increases
Effect of Training on VO2max
Increases
Effect of Training on a-vO2 diff
Increases
Max Heart Rate with Training
Stays same or slightly decreases
Heart Rate Recovery
Faster with training
Ventilation
Movement of air in and out of lungs
Respiration
Gas exchange in the body
External Respiration
Gas exchange between lungs and blood
Internal Respiration
Gas exchange between blood and tissues
Cellular Respiration
Use of oxygen by cells to produce energy
Minute Ventilation (VE)
Tidal Volume × Breathing Rate
Tidal Volume (TV)
Amount of air per breath
Dead Space
Air not involved in gas exchange
Anatomical Dead Space
Air in airways not used for gas exchange
Physiological Dead Space
Total air not used for gas exchange
Surfactant
Reduces surface tension in alveoli
Boyle's Law
Pressure and volume are inversely related
Dalton's Law
Total pressure = sum of partial pressures
Oxygen Transport
Mostly bound to hemoglobin
Carbon Dioxide Transport
Mostly as bicarbonate (HCO3-)
Bohr Effect
Lower pH and higher temp = more O2 released
Hypoxia
Low oxygen levels
Hypercapnia
High carbon dioxide levels
Dyspnea
Shortness of breath
Hyperventilation
Rapid breathing
Valsalva Maneuver
Forced exhale against closed airway
Oxygen Deficit
O2 demand > O2 supply at start of exercise
EPOC
Elevated oxygen use after exercise
Ventilatory Threshold
Point where ventilation increases rapidly
VE/VO2
Ratio of ventilation to oxygen consumption
VE/VCO2
Ratio of ventilation to carbon dioxide production