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Skeletal Muscles
Over 600 skeletal muscles in the body, accounting for 40-50% of body weight.
Functions of Muscles
Breathing, posture, movement, urination, laughing, etc.
Preferred energy source for muscles
Lipids (fatty acids).
Lipoprotein Lipase (LPL)
An enzyme on cell membranes that stores fatty acids in fat cells and helps muscle cells burn fatty acids for energy.
Hormone-Sensitive Lipase (HSL)
An enzyme inside fat cells that breaks down stored fat and releases fatty acids into circulation.
Effect of high insulin levels on LPL
Increases LPL in fat cells (fat storage) and decreases LPL in muscle cells (less fat usage).
Effect of high insulin levels on HSL
Reduces HSL, leading to less fat breakdown.
Thick & Thin filaments
Components of myofibrils in muscle cells.
Muscle cell (fiber)
Made of myofibrils which contain thick and thin filaments.
Fascicle
A bundle of muscle fibers.
Endomysium
Covers muscle fibers.
Perimysium
Covers fascicles.
Epimysium
Covers muscle organs.
Fascia
Covers epimysium and reduces friction.
Tendon
A connective tissue cord that attaches muscle to bone.
Aponeurosis
A broad, flat connective tissue sheet.
Tendon Sheaths
Tube-like structures that enclose tendons.
Origin of a muscle
Fixed attachment that does not move.
Insertion of a muscle
The attachment that moves toward the origin.
Prime Mover (Agonist)
The muscle that directly performs an action.
Antagonist
The muscle that opposes the Prime Mover.
Synergist
A muscle that assists the Prime Mover.
Fixator
A muscle that stabilizes joints.
Lever in the body
Bone, with a fulcrum at the joint and load as the body part being moved.
Class I Lever
Fulcrum is in the middle, e.g., tilting head back.
Class II Lever
Load is in the middle, e.g., standing on toes.
Class III Lever
Effort is applied in the middle, e.g., flexing the forearm.
Muscle Naming - Shape
Named based on shape, e.g., Trapezius (trapezoid).
Muscle Naming - Location
Named based on body location, e.g., Gluteus (buttocks).
Muscle Naming - Size
Named according to size, e.g., Maximus (largest), Minimus (smallest).
Muscle Naming - Action
Named for the action they perform, e.g., Flexor, Extensor.
Muscle Naming - Attachment
Named for attachment points, e.g., Sternocleidomastoid.
Muscle Naming - Number of Heads
Named according to number of heads, e.g., Biceps (2 heads).
Muscle Naming - Fiber Direction
Describes fiber orientation, e.g., Rectus (straight), Oblique (diagonal).
Buccinator
Muscle in the cheeks responsible for smiling, blowing, and sucking.
Masseter
Muscle in the jaw that closes the jaw.
Sternocleidomastoid
Muscle in the neck responsible for head flexion and rotation.
Trapezius
Muscle in the shoulder/upper back that extends the head and shrugs shoulders.
Pectoralis Major
Muscle in the chest known as the hug muscle or for arm adduction.
Latissimus Dorsi
Muscle in the back responsible for posterior arm adduction.
Deltoid
Shoulder muscle responsible for arm abduction/lifting.
Biceps Brachii
Upper arm muscle responsible for forearm flexion.
Triceps Brachii
Upper arm muscle responsible for forearm extension.
Gluteus Maximus
Buttocks muscle responsible for thigh extension and rotation.
Quadriceps Group
Muscles in the thigh responsible for leg extension and kicking.
Hamstring Group
Muscles in the thigh responsible for leg flexion and bending.
Tibialis Anterior
Muscle in the front lower leg responsible for dorsiflexion (foot up).
Gastrocnemius
Muscle in the back lower leg responsible for plantar flexion (pointed toes).
Muscle Functions
Include movement, heat production, and maintaining posture.
Excitable muscle fibers
Muscle fibers that respond to stimuli.
Contractile muscle fibers
Muscle fibers that can shorten.
Extensible muscle fibers
Muscle fibers that can stretch.
Sarcolemma
Cell membrane of muscle fibers.
T-Tubules
Structures that transport nerve impulse into muscle fibers.
Sarcoplasmic Reticulum (SR)
Structure that stores calcium in muscle fibers.
Myofibrils
Structures that contain sarcomeres, the functional unit of contraction.
Sarcomere
Segment of myofibril between Z-lines.
Thick Myofilament
Consists of myosin and forms cross-bridges.
Thin Myofilaments
Include actin, troponin, and tropomyosin.
Sliding Filament Theory
Describes the process of muscle contraction.
Rigor Mortis
Stiff muscles after death due to calcium flooding and no ATP to release myosin-actin bonds.
Muscle Atrophy
Loss of muscle size or strength.
Muscle Tone
Constant slight contraction of muscles for posture.
Muscle Flaccidity
Absence of muscle contraction, often due to nerve damage.
Myalgia
Muscle pain, commonly associated with statin drugs.
Myopathy
A muscle disease characterized by pain, weakness, and wasting.