Syndrome

Down syndrome

Trisomy 21

Underdeveloped Midfacial region

Class 3 small maxilla

Open bite, mouth breather, large tongue, cracked tongue and lips

Missing primary and permanent teeth or delayed eruption

low chance of decay, high chance of periodontal disease

Atrial septal defect

Apert syndrome

M/C craniosynostotic syndrome + syndactyly

Autosomal dominant

Nursing bottle syndrome, (BBTD) baby bottle tooth decay , ECC

Most affected teeth maxi ant. > maxi post. > mandi post. > mandi ant.

Streptococcus mutans

Hyperdontia

Hypodontia

Excess in tooth number

Deficiency in tooth number

Van der woude syndrome

Clefs + lip pits

Melkersson-rosenthal syndrome

Fissure tongue + facial paralysis + granulomatous cheilitis

Sturge - weber syndrome

Angiomas of leptomeninges (arachnoid & pia mater) + skin along the distribution of the trigeminal nerve

Reye’s syndrome

Cause by Aspirin

Rare

Confution, brain swelling & liver damage

Osler-weber-Rendu syndrome

Hereditary Hemorrhagic Telangiectasia

TIE

Telangiectasia

Iron deficiency

Epistaxis

Tx: Bevacizumab

Albergs-schonberg disease or marble bone disease

Osteopetrosis

Dense bone

Brittle & prone to fracture

Autosomal dominant or recessive

Tx: prevent caries and extraction Sx for severe deformity

Peutz - jeghers syndrome (PJS)

Pigmented (melanotic macules) lips/mouth and Jejunal(intestinal) polyp

Colon cancer risk

Sjogren syndrome

Sicca syndrome

Keratoconjuctivits sicca/xeropthalmia (dry eyes)

And xerostomia (dry mouth)

Ramsay Hunt syndrome

HZV reactivation in geniculate ganglion impact on CN 7 & 8 leading to facial paralysis, vertigo & deafness

Tx: Acyclovir

Behcet’s syndrome

Multi system vasculitis

Ulcer in oral , genitals and eye inflammation

Knee inflammation

Swelling and tender ant and post neck

Plummer vinson syndrome

Mucosal Atrophy, dysphasia, iron deficiency anemia

Risk factor of OSCC

The Plumber has a MAD IDeA

Steven-Johnson Syndrome

Toxic epidermal necrolysis

Life threatening blisters and necrotic skin with febrile prodrome oral & ocular involvement

Due to medication

D/D: erythema multiform

Fibroma

Aka hyperplastic scar or traumatic or irritation fibroma

Chronic trauma

M/C connective tissue (CT) tumor

Fibromatosis

Benign,,, aggressive,, high recurrence,, difficult to eliminate

Neoplasm of fibroblasts

Lofgren's syndrome

LANA

Lofgren syndrome, Arthritis, erythema Nodosum, bilateral hilarious lymphAdenopathy

Tx: corticosteroids

Heerford's syndrome

HAPPy

Heerford's, Anterior uveitis, Parotid enlargement, facial nerve Palsy

Tx: corticosteroids

McCune-Albright syndrome (MAS)

Polyostic fibrous dysplasia (Multiple bone)

Cutaneous cafe au lait Spots

Endocrine Abnormalities (precocious puberty)

Goldenhar syndrome

Affect eye, ear, and spine Also some facial structure

Usually unilateral

Digeorge Syndrome

CATCH-22

Cheomosome 22 deletion

Defective neural crest cells , pharyngeal pouches 3&4 (impairment in developing Thymus and Parathyroid glands)

Cardiac abnormalities

Abnormal facies

Cleft palate

Hypocalcemia