Viruses, Vaccines, and Pathogenesis Review Questions

What virus has been eradicated?

Smallpox

Many mammalian viruses have protein coats made of repeating subunits called protomers. Where does a mammalian virus typically get its protomers?

They are encoded by genes in the virus genome

Bacterial Viruses (“Bacteriophages”) have protein coats made of repeating subunits called protomers. Where does a bacteriophage typically get it’s protomers?

They are translated from viral mRNA (Virus Genome)

What is the structure labeled B?

Nucleic Acid 

What is the structure labeled A?

Capsid

What is this overall structure?

Nonenveloped Virus

What is the structure labeled C?

Envelope

What is the structure labeled D?

Spike

What is the structure labeled E?

Capsid

What is the structure labeled F?

Nucleic Acid

What is this overall structure?

Enveloped Virus

What is the structure labeled G?

Promoter

What is the structure labeled H?

RNA

What is the overall structure?

Helical Capsid

Phage lambda genome (Baltimore Group I) make

DNA Polymerase

Influenze genome (Baltimore Group V) make

RNA-dependent RNA polymerase 

Influenza Envelope make 

Metabolic Enzymes

Phage U136B Tail Fiber make

Ribosome

Influenza mRNA

RNA-dependent RNA Polymerase

Coronavirus mRNA

RNA-dependent RNA Polymerase 

Ribosomal RNA make

RNA Polymerase

Envelope Proteins make

Ribosome

Capsid Subunit (Promoter) make

Ribosome

Which of the following organismal types use ribosomes to make proteins?

Bacteria, Viruses, Archaea, Eukaryotes (ALL OF THE ABOVE)

Which of the following organismal types have a genome encoded by RNA?

Viruses in Baltimore Groups III through Group VI

Which of the following organismal types can be inhibited by a medication that targets reverse transcriptase?

Viruses in Baltimore Group VI (6)

Which of the following organismal types typically have genomes that are at some point in their life cycle made of DNA?

Bacteria, Eukaryote, Viruses in Baltimore Group VI (6) and VII (7), all viruses bacteria archaea and eukaryotes (ALL OF THE ABOVE)

can have a nucleus 

Eukaryotes

have proteins that are made by ribosomes

All of the above - Viruses, Bacteria, Eukaryotes, Archaea

Can have a DNA genome

All of the above - Viruses, Bacteria, Eukaryotes, Archaea

Can have an RNA genome

Viruses

can have an RNA genome that never has a DNA intermediate

Viruses

can have an RNA genome that has a DNA intermediate

Viruses

can have a genome surrounded by a capsid 

Viruses

Can have a genome enclosed in a nucleus

Eukaryotes

Can be killed by a drug that targets the bacterial ribosome

Bacteria

can be killed by a drug that targets RNA dependent RNA polymerase

Viruses

can be killed by a drug that targets peptidoglycan synthesis

Bacteria

Influenza (Baltimore Group V (5)) would be best treated by a drug that targets

RNA dependent RNA polymerase

What process is A?

Transcription

What process is B?

Replication

What process is C?

Transcription

What process is D?

Translation

What process is E?

Assembly