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Scaly Dermatoses: exclusions
general dandruff, SD, Psoriasis
Psoriasis specific
general dandruff, SD, Psoriasis
less than 2 years old
worsening, no improvement after 2 weeks of SC
Psoriasis specific
more than 5% BSA
face involvement
joint pain (psoriatic arthritis)
many/large lesions
Scaly Dermatoses: pharm treatments and its MOA
Selenium Sulfide
Pyrithione Zinc
MOA
inhibit scalp fungus
cytostatic effect
which is good for 1st line? which is more potent?
1st line = pyrithione zinc
potent = selenium sulfide
pyrithione zinc
strength
scheduling/use
ADRs
counseling
strength
1 - 2%
scheduling/use
initial/acute = daily to 1 - 2x week
controlled = 2 - 3x week (BIW-TIW) for 2 - 4 weeks
maintenance = 1x every 1 - 2 weeks
wash w/ non-med → zinc 3 - 5mins, rinse
ADRs
CD
eye irritation
counseling
leave zinc for 3 - 5 mins
avoid contact w/ eyes
skin irritation
selenium sulfide
strength
scheduling/use
ADRs
counseling
strength
1%
scheduling/use
initial/acute = daily to 1 - 2x a week
controlled = 2 - 3x week for 2 - 4 weeks
maintenance = 1x every 1 - 2 weeks
wash w/ non-med, leave 3 - 5mins, rinse 2 - 3x
ADRs
CD
eye irritaion
residual oil
potential hair color
counseling
same as Pyrithione + rinsing 2 - 3x
diaper dermatitis prevention + treatment
A
B
C
D
E
A
air dry
diaper off
B
barrier
lubricate area, prevent moisture
thick layer
zinc oxide = strong barrier
petrolatum = occlusive
talc (carcinogenic), cornstarch → not recommended
C
cleansing
change frequently
clean w/ soft cloth, warm water
D
change diaper every 2 hrs or immediately
disposable
not tight-fitting
E
educate hygiene, use/application of pharm, understanding
which is not recommended for diaper dermatitis
topical antibiotics, antifungals, steroids
diaper dermatitis: exclusions
lesions persist 7+ days or lack of improvement
s/sx secondary prevention
outside diaper area
UTI
broken skin, blood, vescicles, pus
comorbid conditions
s/sx systemic
chronic, frequent, recurrent sx
behavioral changes
Diarrhea: exclusions
less than 6 months, 17.5 lbs
fever
blood, mucus, pus
high volume output, frequency
vomiting
dehydration
abdominal pain, distention, tenderness
complications
pregnancy
chronic
sx worsen after 48 hrs of onset
ORS
Diarrhea: Non-pharm
ORT (Pedialyte)
prevent electrolyte loss
avoid sports drink, sodas, juices, chicken broth
do not withhold food for 24 hours
Diarrhea: pharm therapy (sx control only)
not used more than 48 hours
Loperamide (Imodium A-D)
Bismuth Subsalicylate (BSS) (Pepto-Bismol)
Loperamide (Imodium A-D)
mild-mod in pts ≥ 6 years old afebrile, no blood or mucus
adults (≥12)
4 mg (2 tabs) → 2 mg (1 cap) after each stool
max: 8mg/day
ADR
dizziness, constipation
caution
heart warning
Bismuth Subsalicylate (BSS) (Pepto-Bismol)
mild-mod acute in pts ≥ 12 years old afebrile, no blood, mucus
tabs: 525 mg q30 - 60 mins PRN
liquid: 15 - 30 mL q30 - 60 mins PRN
max: 4200 mg/day
do not use more than 48 hrs
ADRs
black/tarry stools
discoloration tongue
tinnitus
caution
do not use in aspirin allergy
Reyes Syndrome (do not give to viral infected pts)
caution in anticougulant
separate admin by 2 hrs if taking antibiotics
Otic disorders: referral
less than 12 years old (cerumen)
sx of infections
pain w/ ear discharge
bleeding/trauma
typanostomy tubes
ruptured tympanic membrane
ear surgery past 6 weeks
hypersensitivity
worsen/persist after 4 days of SC
impacted cerumen medication
Carbamide Peroxide
5 - 10 drops 2x day each ear
max 4 days
head tilted for 5 mins
water clogged ears medication
isopropyl alcohol + anhydrous glycerin
4 - 5 drops in each ear
remain 1 - 2 mins
max: 4 days
Lice: exclusions
less than 2 months (permethrins Nix)
less than 2 years (pyrethrins Rid)
allergies
chrysanthemums, pyrethrins
ragweed
conditons
secondary infections
eyebrow/lid infestations
pregnancy/lactating
tumors
resistance to pediculicides
products for lice
RID (Synergized pyrethrins)
NIX (Permethrin 1%)
RID (Pyrethrins)
active ingredient
indications
applications/use
counseling
ADRs
active ingredient
pyrethrins + piperonyl butoxide
indications
head, pubic lice
applications/use
apply, leave on for 10 mins
rinse hair
nit comb
repeat 7 - 10 days required
counseling
mandatory repeat treatment
nit combing
irritation/sx persist after 2nd treatment
ADRs
minimal, mild skin irritation
NIX (Permethrin 1%)
active ingredient
indication
application/use
counseling
ADRs
active ingredient
permethrin
indication
head lice
application/use
shampoo, rinse, dry
apply, leave on 10 mins
rinse
nit comb
NO REPEAT needed unless live observed 7 - 10 days
counseling
repeat not needed
nit comb
med attention if irritation/sx persist
ADRs
minimal, mild skin irritation
DSHEA regulation
dietary supplement health and education act
primairy regulatory framework for DS
excluded from strict purity and potency standards
manufacturer responsible for safety and efficacy
no pre-market clinical trials required
manufacturers must notify FDA 75 days before marketing new dietary ingredient (NDI)
labeling requirements
ID statement: DS
net quantity of contents
supplement facts panel: nutrients, servings, % daily value
ingredients list
manufacturer/distributor info
directions of use
botanical products → plant’s scientific name, part used
labeling claims
structure function permitted
disclaimer: “not evaluated by FDA. not intended to diagnose, treat, cure, prevent disease
health, nutrients content claim → allowed but need FDA approval
adulteration
composition and safety of product
presents risk of illness/injury
imminent hazard
poisonous ingredients
misbranding
manufacturer fails to follow required labeling
insomnia: exclusions
less than 12 years old or over 65 years old
pregnant/breastfeeding
frequent nocturnal awakening or early morning awakenings
chronic sx ≥ 3x/week for at least 3 months
secondary causes
insomnia: supplements
melatonin → max use 10 days
valerian, chamomile → no benefit
insomnia medication
antihistamines (Diphenhydramine)
for transient, short term insomnia
max use 7 - 10 consecutive nights
50 mg diphen HCl; 76 mg diphen citrate
antihistamines
ADE
DDIs
CI
counseling
ADE
anti-SLUD
CNS effects
paradoxical excitation - children, elderly, hx mental disorders
toxicity - coma, seizures
DDIs
alcohol + CNS depressants
CYP2D6 (Metoprolol)
CI
BPH
angle closure glaucoma
CVD
dementia
counseling
avoid alcohol
caution in activities
hangover effect
avoid other AHs
insomnia: recommendations, management
sleep hygiene
diphenhydramine 2 - 3 nights if needed
reassess
sx resolved → d/c med, continue sleep hygiene
sx persist → cont diphenhydramine max 7 -10 days before referral
constipation: exclusions
less than 2 years old
abdominal pain, distention, cramping
flatuence
n/v/d
anorexia/weight loss
bloody, dark, tarry
sx last more than 2 weeks
sx recur over period of ≥ 3 months
sx reoccur ≥ 7 days of SC
daily use of non-rx laxative
paraplegia/quadriplefia, IBD, colonstomy
fastest onset of action laxatives
saline (rectal) = 2 - 15 mins
glycerin suppositories (rectal) = 15 - 30 mins
stimulant (rectal) = 15 - 60 mins
intermediate onset of action laxatives
saline (oral) = 0.5 - 6 hrs
stimulant (oral) = 6 - 10 hrs
slowest onset of action laxatives
bulk forming = 12 - 72 hrs
hyperosmotic (PEG 3350) = 12 - 96 hrs
emollient (stool softeners) = 12 - 72 hrs
bulk forming laxatives
products
onset of action
MOA
ADR
counseling
products
Psyllium
methylcellulose
Polycarbophil
onset of action
slowest (12 - 72 hrs)
MOA
mimics insoluble dietary fiber
ADR
cramping
bloating
flatuence
counseling
DOC
mix/take dose w/ 8oz water
separate other meds by at least 2 hrs
hyperosmotic laxatives
products
onset of action
MOA
ADR
counseling
products
PEG 3350
onset of action
slowest (12 - 96 hrs)
MOA
draw water into colon via osmosis
soften stool
increase bowel movements
ADR
bloating
abdominal pain
counseling
dissolve 17 g in 4 - 8 oz beverage
do not use more than 7 days
emollient laxatives (stool softeners)
products
onset of action
MOA
counseling
products
Docusate
onset of action
slowest (12 - 72 hrs)
MOA
increase wetting of fecal mass; all mush no push
counseling
take w/ full glass of water
do not take with mineral oil
recommended for pts on opioids or postpartum
glycerin suppositories
onset of action
MOA
ADR
counseling
onset of action
fastest (15 - 30 mins)
MOA
local irritant in rectum
draws water out of rectum
ADR
minor rectal irritation
counseling
avoid in pts w/ rectal inflammation/ulceration
saline laxatives
products
onset of action
MOA
ADR
counseling
products
Mg Hydroxide
Mg citrate
onset of action
fastest (rectal) = 2 - 15 mins
intermediate (oral) = 0.5 - 6hrs
MOA
non-absorbable ions draw out water into intestines thru osmosis
ADR
cramping
dehydrating
n/v
electrolyte imbalance
counseling
take with 8 oz water
take on empty stomach
which saline laxative product is for occasional constipation? acute blowel evacuation?
mg hydroxide (milk of magnesia) = occasional constipation
mg citrate, na phosphate = acute bowel evacuation
stimulant laxatives
products
onset of action
MOA
ADR
counseling
products
Senna
Bisacodyl
onset of action
fastest (rectal) = 15 - 60 mins
intermediate (oral) = 6 - 10 hrs
MOA
stimulate colonic myenteric plexus
irritate GI lumen
ADR
cramping
nausea
counseling
in combo with stool softener for opioid-induced constipation
which stimulant laxative product causes pink/red/orange urine?
Senna
counseling for Bisacodyl
do not chew/crush tabs
do not take within 1 hr of antacids, H2RAs, PPIs, milk
Atopic dermatitis: exclusions
involvement of large area of body, face, or intertriginous areas
less than 1 year old
skin infection
atopic dermatitis: non-pharm
identify/eliminate triggers
Humidifiers
Avoid sudden changes in temp and humidity
Short, clean nails
Cotton sheets and clothing
Bathing in lukewarm, hypoallergenic/fragrance free soaps
Emollients for moisturizing
Diluted bleach bath (BID, recurrent skin infections)
Wet wrapping
atopic dermatitis: pharm
Corticosteroids
Anti-inflammatory
Hydrocortisone cream = DOC
Ointment = thickened, dry, scaly skin
BID
Safe for > 2 years old
Risk of tachyphylaxis → use 1x or 2x weekly
Avoid when lesions weeping, skin infected cracked, opened, refractory cases
Antihistamines
Relieve pruritus
Topical diphenhydramine often used (not oral)
Cooling effect
Potential risk of contact dermatitis
T or F: hydrocortisone cream is okay to use for lesions weeping, skin infected, cracked, opened?
F → use ointment version instead of cream
contact dermatitis: exclusions
< 2 years old
Present for > 1 week; chronic
> 10% BSA effected (ICD); > 20% BSA effected (ACD)
Itching, many large vesicle/bullae formation, edema
Genitalia, mouth, eyes, nose, anus, face, scalp, neck involvement
Secondary infection
Failure of self care after 7 days
Impairments of ADLs
contact dermatitis: non-pharm
Wash w/ mild soap
Clip fingernails
Avoid scrubbing or harsh cleaners
Wash contaminated clothing
Shower (cold or tepid temps)
Avoid bathing
contact dermatitis: pharm
bentoquatam
tecnu
zanfel
astringents
skin protectants
corticostertoid
Bentoquatam
use
application
counseling
recommendation
use
prevention
application
apply to clean, dry skin 15 mins before exposure
cover exposed areas
reapply every 4 hrs
wash with soap
counseling
do not apply to open wounds/irritated skin
practice good hygiene
recommendation
those entering areas w/ poison ivy, oak, sumac
Tecnu
use
application
counseling
use
prevent rash immediately after exposure
application
apply to exposed skin
rub vigorously for 2 mins
rinse w/ water or wipe
counseling
most effective used within mins - hrs of exposure
effective for 8 hrs
reapply PRN
Zanfel
use
application
counseling
use
aim to remove/inactivate urushiol
treats rash after appearing, rapid relief
application
wet area
dispense product to hands
rub + apply + rub for 3 mins
rinse
repeat if needed
counseling
relief within 30 secs of washing
not preventative
astringents
use
products
use
barrier, cooling, itch relief
products
Aluminum acetate
witch hazel
skin protectants
use
products
use
block irritants
lock in moisture
apply PRN to affected area
products
oatmeal
zinc oxide
titanium dioxide
calamine
corticosteroid
use
product
counseling
use
temporary relief of pruritus, skin irritation, inflammation, rash
BID for up to 7 days
product
hydrocortisone 0.5 - 1%
counseling
thin layer
do not use more than 7 days
avoid long term use
wash hands before/after application
pinworm
medication
dose
medication
pyrantel pamoate
dose
11 mg/kg (base) x 1 single oral dose
max: 1 g
may repeat in 2 weeks if sx persist
oral care: exclusions (canker, cold sores)
lesions present ≥ 14 days, recurring, worsening
systemic infection
immunocompromised
failure of SC after 7 days
fluoride
use
types
use
resistance to enamel demineralization
remineralization of lesions of enamel
interferes w/ bacterial cariogenic process and w/ plaque adherence
types
sodium fluoride
sodium monofluorophosphate
stannous fluoride
cold sores (HSL): non-pharm
Wash lesions gently with mild soap and water
avoid triggers (wear lip sunscreen/SPF)
wash hands frequently to avoid spreading or autoinoculation
avoid kissing or sharing utensils/towels while active
cold sores (HSL): pharm
topical skin protectants
3 - 4x day
protection, relieve dryness
topical oral anesthetics
“-caines”, dyclonine, camphor, menthol
relief
Docusanol 10%
reduce duration + severity
apply at 1st sign, 5x day, up to 10 days
cancer sores: non-pharm
goog hygiene
increase nutrients
avoid spicy foods, sharp foods
apply ice 10 mins increments
salt rinse or baking soda paste
cancer sores
pharm
counseling
pharm
hydrogen peroxide 1.5%
carbamide peroxide 10%
topical anesthetics, protectants
NSAIDs, APAP
counseling
3 - 4x day no more than 7 days
chronic use → tissue irritation, decalcification
xerostomia (dry mouth): exclusions
Tooth erosion
Candidiasis, gingivitis, periodontitis
Reduced denture wearing time
Mouth soreness
Severe tooth pain
fever/swelling
Loose teeth, bleeding gums, broken teeth
Sjogren
Salivary gland stones
Symptoms severity does not decrease
xerostomia (dry mouth): non-pharm
Avoid cigs and tobacoos
Do not use alcohol containing products
Avoid caffeine and hot/spicy foods
Limit consumption of sugary, starchy, acidic foods
Chew gum w. Xylitol to increase flow of saliva and drink water
Use cool list humidifier to moisten air
xerostomia (dry mouth): pharm
Artificial saliva products w/ fluoride
Relieve discomfort
Mimic natural saliva
Does not stimulate salivary glands
Can be used on PRN
NV: exclusions (children)
Signs of severe dehydration are present
The caregiver is unable to manage the children’s N/V
N/V + 1 of these (summarized):
stiff neck
< 6 months of age or weight < 17.6 lb
Lack of urination in the past 8-12 hours
<1 month of age with three large diarrhea stools
< 12 weeks of age with fever
< 1 year of age with eight diarrhea stools in last 8 hours
Severe headache > 2 hours
NV: exclusions (adults - summarized)
Dehydration
blood in vomit
abdominal pain
stiff neck
NV (motion sickness): product recommendation
1st gen AH
Dimenhydrinate (Dramamine)
50 - 100 mg every 4 - 6hrs
max: 400 mg/day
take 30 - 60 min before exposure
Diphenhydramine (Benadryl)
25 - 50 mg every 4 - 6 hrs
max: 300 mg/day
take 30 mins before exposure
Meclizine (Bonine)
25 - 50 mg
max: 50 mg/day
take 1 hr before activity
NV: non-pharm general
ORS
restore electrolytes
take 10 mins after last episode of vomiting
avoid other fluids before or after ORS
general
eat small meals every 1 - 2hrs
avoid hot/humid environments
sips of carbonated drinks or fruit juices
minimize exposure to strong smells, loud noises, bright lights
good ventilation
NV: non-pharm motion sickness
Sit where motion is lowest (or drive)
look straight ahead at the horizon
avoid looking down
Avoid excessive food, alcohol, and strong odors (food/tobacco) before and during travel