Respiratory System II Pathology Flashcards

Flashcards about Respiratory System II Pathology, based on lecture notes.

Squamous cell papilloma

Benign tumor arising from an epithelial surface and usually known to grow in an outward direction. Usually occur in large bronchi, often with associated tracheal or laryngeal lesions.

Squamous cell papilloma Gross Description

Tan-white, friable, pedunculated / polypoid, smooth to verrucoid, glistening. Wart-like, cauliflower-like. Less than a few centimeters in size

Squamous cell papilloma Microscopic Description

Exophytic, papillary lesion with arborizing fibrovascular cores lined by keratinizing or nonkeratinizing mature squamous epithelium

Lung cancer

The leading cause of cancer-related deaths worldwide, accounting for the highest mortality rates among both men and women.

Squamous cell carcinoma

Malignant tumor arising from epithelial cells with squamous differentiation demonstrated either immunohistochemically or morphologically, with the presence of keratinization or intercellular bridges.

Squamous cell carcinoma Gross Description

Cavitary mass with white, smooth cut surfaces that frequently contain hemorrhage and necrosis. Mass is more often central than peripheral and may be within the bronchus.

Alveolar adenoma

Well circumscribed tumor consisting of cystic spaces lined by a single layer of type II pneumocytes overlying a spindle cell stroma.

Alveolar adenoma Microscopic Description

Cystic spaces filled with eosinophilic granular material. Lined by cytologically bland flattened to cuboidal epithelial cells (pneumocytes type II). Myxoid or collagenous stroma.

Lung adenocarcinoma

Most prevalent non-small cell lung carcinoma.

Lung adenocarcinoma Gross description

Tan-white cut surface. May have central area of scar or necrosis. Usually well-defined but nonencapsulated

Lepidic Lung adenocarcinoma Microscopic description

Type II pneumocytes and club cells proliferate to line alveolar walls; lacks architectural complexity; no lymphovascular or perineural invasion

Acinar Lung adenocarcinoma Microscopic description

Gland forming; round / oval glands invading the stroma (usually fibrous)

Papillary Lung adenocarcinoma Microscopic description

Malignant cuboidal / columnar cells replace alveolar lining; contains fibrovascular cores.

Micropapillary Lung adenocarcinoma Microscopic description

Ill-defined projection / tufting that lacks fibrovascular cores.

Solid Lung adenocarcinoma Microscopic description

Sheets of neoplastic cells