Module 12

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70 Terms

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respiratory system function
* supply body tissues with oxygen\\
* dispose of CO2
* supply body tissues with oxygen\\
* dispose of CO2
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respiration includes…
* pulmonary ventilation
* gas exchange
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alveoli
* saclike dilation
* site of gas exchange with the blood
* big surface area in contact with capillaries for quick diffusion
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elasticity
tendency of a structure to recoil to its initial dimensions after being distended
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acidosis
increase in H+ concentration of the blood that lowers pH
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type 1 alveolar cell
forms continuous layer lining the air-facing surface of the pulmonary alveoli
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hypoventilation
plasma concentration of CO2 is abnormally increased, inadequate pulmonary ventilation
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boyle’s law
pressure of given quantity of a gas is inversely proportional to its volume
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alkalosis
decrease in H+ concentration of blood that raises pH
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partial pressure
pressure of a particular gas in a mixture
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transpulmonary pressure
pressure difference keeping the lungs against the chest wall
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diaphragm
primary muscle of ventilation
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lung compliance
change in lung volume per change in transpulmonary pressure
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chemoreceptor
receptor sensitive to chemical changes such as pH, O2, CO2
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deoxyhemoglobin
produced when oxyhemoglobin releases oxygen
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ventilation
exchange of air between atmosphere and alveoli
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oxyhemoglobin
oxygen bound on hemoglobin
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hyperventiliation
high rate and depth of breathing resulting in a decrease in blood CO2 concentration below normal
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intrapleural space
potential space between the visceral and parietal linings
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surfactant
reduces surface tension between fluid and alveolar surface, increases lung compliance
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intrapulmonary space
space within air sacs and airways
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type 2 alveolar cell
pulmonary cells that produce surfactant
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pulmonary ventilation
exchange of air between atmosphere and alveoli
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components of gas exchange
* external respiration
* internal respiration
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external respiration
* movement of O2 from lungs into blood
* CO2 from blood to lungs
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internal respiration
* movement of O2 from blood into tissue cells
* CO2 from cells into blood
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upper airway
air comes in and travels to larynx
air comes in and travels to larynx
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air way ends at the
alveolar sacs
alveolar sacs
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respiratory zone
where gas exchange happens
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conducting zone
everything else
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epithelial surfaces contain…
cilia
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cilia
secrete mucus and keep lungs clear of particulate matter
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particulates
dust, foreign contaminants
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in the respiratory zone the air is…
* 37 degrees C
* temp and moisture is constant
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respiratory system located in …
thorax (neck to diaphragm)
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lungs
passive, elastic, volume fluctuates
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all pressures are relative to…
atmospheric pressure (760mm Hg at sea level)
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inverse relationship between
pressure and lung volume
pressure and lung volume
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intra-alveolar pressure (intrapulmonary)
changes to drive movement of air
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pressure equation
P(transpulmonary) = P(alveolar) - P(intrapleural)
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intrapleural pressure is always less than
alveolar pressure
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intrapleural pressure
pressure in pleural space
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inspiration initiated by
motor neurons firing APs to intercostal muscles and diaphragm
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most important inspiratory muscle
diaphragm
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active movement
inspiration
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expiration initiated by
motor neurons decrease APs to diaphragm and intercostal muscles, causing them to relax
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passive movement
expiration
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role of nervous system
* receive info
* processes and responds
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respiratory rhythm generated in…
medulla oblongata
medulla oblongata
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motor neurons
breathing depends on these muscle movements, especially diaphragm
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carotid bodies
strategically located to monitor oxygen supply to brain
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peripheral cemoreceptor
responding to changes in H+ concentration
responding to changes in H+ concentration
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input from receptors modifies
rate and depth of breathing
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when muscles contract in chest wall
chest expands
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during inspiration…
diaphragm contracts downward and the thoracic cavity is larger
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dalton’s law
the pressure each gas exerts is independent of the pressure of other gases
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oxygen diffuses from
alveoli to plasma (high to low concentration)
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during exercise
the O2 gradient from blood to tissue increases
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2 forms of oxygen in blood
* dissolved in plasma and erythrocyte cytosol
* combined with hemoglobin molecules in erythrocyte
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heme
iron-containing pigment, binding site
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factors affecting movement of O2 on hemoglobin to tissues
* concentration
* affinity (changes in pH or temp can affect affinity)
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affinity should be
sufficient to hold bond of O2 to the iron on hemoglobin but not so high that it prevents unloading
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only dissolved O2 contributes to
pressure of O2 of the blood
pressure of O2 of the blood
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CO2 produces
H+ which causes toxicity
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forms of transport for CO2
* 10% dissolves in plasma
* some react with hemoglobin
* 60-65% is converted to HCO3-
* 10% dissolves in plasma
* some react with hemoglobin
* 60-65% is converted to HCO3-
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CO2 movement in tissues and lungs
* chloride shift retains electrical neutrality of cell
* H+ in red blood cell buffered by deoxyhemoglobin, H+ in plasma buffered by bicarbonate moving out
* bicarbonate builds up, leaves down its gradient
* Cl- is attracted into cell with movement of bicarbonate and trapping of H+
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range for pH of blood
7\.35-7.45
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blood pH maintained thru
* lungs regulate CO2
* kidneys regulate bicarbonate
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respiratory acidosis
arterial H+ concentration increased due to CO2
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respiratory alkalosis
results from decreased arterial CO2 pressure and H+ concentration