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Methionine
Nonpolar - nonaromatic
Sulfur atom in side chain
Met
M

Glycine
Nonpolar, nonaromatic
Single H in side chain
The only achiral AA
Smallest AA
Gly
G

Alanine
Nonpolar, nonaromatic
Side chain: Methyl group
Hydrophobic
Ala
A

Valine
Nonpolar, nonaromatic
Side chain: Isopropyl variable
Hydrophobic
Val
V

Leucine
Nonpolar, nonaromatic
Side chain: Isobutyl
Hydrophobic
Leu
L

Isoleucine
Nonpolar, nonaromatic
Side chain: Hydrocarbon
Hydrophobic
Ile
I

Proline
Nonpolar, nonaromatic
Forms a cyclic AA
Unique: Amino Nitrogen becomes part of side chain instead of at alpha C
Side chain: Forms 5-membered ring - limits where AA can appear and constrains Secondary structure
Pro
P

Tryptophan
Non polar, Aromatic side chain
Largest of the aromatics
Side chain: Double ring containing Nitrogen
Trp
W

Phenylalanine
Non polar, Aromatic side chain
Smallest aromatic
Side chain: Benzyl (Benzine with CH2 group)
Hydrophobic
Phe
F

Tyrosine
Polar, Aromatic side chain
Side chain: Benzyl with an OH group
Tyr
Y

Serine
Polar, Non-aromatic
Side chain: Hydroxylmethyl (Methyl with an OH)
Involved with H-bonding
Ser
S

Threonine
Polar, Non-aromatic
Side chain: Alcohol
Involved with H-bonding
Thr
T

Asparagine
Polar, Non-aromatic
Side chain: amide (The O double bond points down)
The side chain N does not gain or lose proteins
Asn
N

Glutamine
Polar, Non-aromatic
Side chain: Amide (The O double bond points up)
The side chain N does not gain or lose proteins
Gln
Q

Cysteine
Polar, Non-aromatic
Side chain: Thiol (SH group)
Prone to oxidation
Cys
C

Aspartic Acid (Aspartate)
Negatively charged (Acidic)
Side chain: COO- (Double bond points down)
Notice it is acidic
Hydrophilic
Asp
D

Glutamic Acid (Glutatmate)
Negatively charged (Acidic)
Side chain: COO- (double bond O points up)
Notice it is acidic
Hydrophilic
Glu
E

Lysine
Positively charged (Basic)
Side chain: Terminal primary amino group
Hydrophilic
Lys
K

Arginine
Positively charged (Basic)
Side chain: 3 N atoms
Hydrophilic
Arg
R

Histidine
Positively charged (Basic)
*Is neutral at pH of 7.4*
Side chain: Aromatic ring with 2 N atoms
Hydrophilic
His
H
