Antidiabetics: GLP-1 Agonists and Insulin

What do GLP-1 agonists do?

-Slow gastric emptying

-Curb appetite

-Help insulin release

Indications for GLP-1 agonists: ________, ________

-Type 2 diabetes

-Obesity

Side effects of GLP-1 agonists: ________, _________, ________

-GI upset

-Pancreatitis

-Thyroid cancer

Interactions with GLP-1 agonists: __________, _________

-CI with thyroid cancer history

-Hypoglycemia with other antidiabetics

Side effects of insulin: _______, __________

-hypoglycemia

-weight gain

Interactions with insulin: ________, ________

-Beta blockers mask hypoglycemia

-Hypoglycemia with other antidiabetics

Exenatide

Byetta, Bydureon

antidiabetic

Dulaglutide

Trulicity

antidiabetic

Liraglutide

Victoza, Saxenda

antidiabetic

Semaglutide

Ozempic, Wegovy, Rybelsus

Antidiabetic

Tirzepatide

Mounjaro, Zepbound

Antidiabetic

Insulin aspart

Novolog

Rapid onset insulin

With meals

Insulin lispro

Humalog

Rapid onset insulin

With meals

Insulin regular

Humulin R, Novolin R

Short-acting onset insulin

with meals

Insulin NPH

Humulin N, Novolin N

Intermediate onset insulin

taken every 12 hrs for a baseline insulin throughout the day

Insulin detemir

Levimir

Long-acting insulin

Insulin glargine

Lantus, Toujeo

Long-acting insulin

Insulin degludec

Tresiba

Ultra-long insulin