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BA Sequestrants MOA
Binds bile acids in intestinal lumen preventing reabsorption
BA Sequestrant PK
NOT absorbed systematically
Colestipol dosage
5g per day up to 20g
Cholestyramine Oral Suspension dosage
4g per day (20g max)
Colesevelam dosage
3750mg tablets in 2 or 3 divided doses
BA sequestrants adverse effects
Bloating
Abdominal discomfort
Constipation
Indigestion
Decreased ADEK absorption
BA Sequestrants precautions
Avoid: px w diverticulitis
Binds other negatively charged drugs
Fetal harm not expected
Negatively charged drugs that interact
Digoxin
Thiazides
Warfarin
Teracyclines
Thyroxine
Pravastatin
Fluva
Ezetimibe
Folic acid
Aspirin
Ascorbic acid