Autoimmune Diseases and Hypersensitivities

What type of immune hypersensitivity is Type I Diabetes?

Type II.

What is the autoantigen in Type I Diabetes?

Insulin.

What type of immune hypersensitivity is Rheumatoid Arthritis?

Type III and IV.

What is the autoantigen in Rheumatoid Arthritis?

IgM/IgG rheumatoid factor

What type of immune hypersensitivity is Psoriasis?

Type IV.

What is the autoantigen in Psoriasis?

LL-37.

What type of immune hypersensitivity is Multiple Sclerosis?

Type IV and II.

What is the autoantigen in Multiple Sclerosis?

Myelin

What type of immune hypersensitivity is Systemic Lupus Erythematosus (SLE)?

Type III.

What is the autoantigen in Systemic Lupus Erythematosus?

Cell nucleus components (dsDNA/ssDNA)

What is the autoantibody in Systemic Lupus Erythematosus?

Anti-dsDNA, ssDNA, RNA, anti-organelle

What type of immune hypersensitivity is Inflammatory Bowel Disease?

Type IV.

What is the autoantigen in Inflammatory Bowel Disease?

Gut microbiota.

What type of immune hypersensitivity is Addison’s Disease?

Type II and IV.

What is the autoantigen in Addison’s Disease?

21-hydroxylase.

What type of immune hypersensitivity is Graves’ disease?

Type II.

What is the autoantigen in Graves’ Disease?

TSH receptors.

What is the autoantibody in Graves’ Disease?

Anti-TSH receptor.

What type of immune hypersensitivity is Hashimoto’s Thyroiditis?

Type II.

What is the autoantigen in Hashimoto’s Thyroiditis?

Thyroid peroxidase/thyroglobulin

What is the autoantibody in Hashimoto’s Thyroiditis?

Anti-TP and TG.

What type of immune hypersensitivity is Myasthenia Gravis?

Type II.

What is the autoantigen in Myasthenia Gravis?

Acetylcholine receptor.

What is the autoantibody in Myasthenia Gravis?

Anti-acetylcholine receptor.

What type of immune hypersensitivity is Pernicious Anemia?

Type II.

What is the autoantigen in Pernicious Anemia?

Intrinsic factor.

What type of immune hypersensitivity is Celiac Disease?

Type II and IV.