Ethanol

What takes ethanol to acetaldehyde

alcohol dehydrogenase

NAD+—>NADH

what inhibits alcohol DH

fomepizole and methanol

What type of kinetics is on alcohol DH

0

acetaldehyde —> acetate

what enzyme

acetaldehyde DH

NAD+—→ NADH

What inhibits acetaldehyde DH

disulfiram

NAD+ to NADH

H2O2 goes to H2O through what enzyme ?where

catalase peroxisome

What enzyme ___ amt of alc induces

NADPH + H+ + O2 —> NADP+ to 2H2O

CYP2E1

Large amts

Don’t take Tylenol when drinking bc it stimulate

NAPQI

GSH

want to increase GSH LVLS

What ratio is increased

NADH/NAD+

What processes decreases

Gluconeogenisis

TCA

__ % of alc evaporates in breath and sweat or urine. The rest in bloodstream

10%

Effects acetaldehyde

damage cells: liver brain pancreas GI tract

impair memory and coordination

sleepiness

In Asians what is defecient

Acetaldehyde DH

decreased alc disorder

increase esophageal cancer

increased NADH TO NAD+ prevents lactate to Pyruvate which results in

Lactic acidosis

Inhibition gluconeogenisis DH enzyme

Fasting hypoglycemia

G3P combine fatty acid to TG lead to

Hepatosteatosis (fatty liver)

Lower gluconeogenisis, ketogenesis lead to

anion gap metabolic acidosis

Methanol

Toxic to wood alc

Lead to blindness basal ganglia injury

Brain damage acidosis

Ethylene glycol

Active chem in antifreeze

glyoxylic acid and oxalic acid toxic effect

Lactic acidosis

forms calcium oxalate —> acute tubular necrosis and renal failure

Anion gap

Quantities diff btwn cation (+) and anion (-) serum plasma urine

(Na+) + [k+] — ([Cl-]) + ([HCO3-])

Wernicke encephalopathy

Erythrocyte transketase (thiamine)