Not-So-Usual-Suspects

Diego

- clinically significant

- "a" high in South American Indians

Diego: Why not on antigram?

High/Low Frequency Pair

Dia = Low / Dib = High

Wra = Low / Wrb = High

Cartwright: Why not on antigram?

High/Low Frequency Pair

Yta = high / Ytb = low

Cartwright

- variable clinical significance

- some HTR, no HDN

- Ytb more common in Israeli's

- sensitive to DTT

X-Linked Gene - Xga

- not clinically significant

- more common in females than males

- sensitive to enzymes, resistant to DTT

Colton

- clinically significant

- enhanced with enzymes

- function = water transfer

Landsteiner-Weiner: Why not on antigram?

High/Low Frequency Pair

Lwa = High / Lwb = Low

Landsteiner-Weiner

- weaker on D negative cells

- only null is Rh null

- sensitive to DTT

Chido/Rodgers: Why not on antigram?

Clinically Insignificant

Chido/Rodgers

- high frequency

- compliment absorbed

- neutralized by normal plasma

- destroyed by enzymes, resist DTT

Xga: Why not on antigram?

- not clinically significant

- sometimes on antigram

Scianna: Why not on antigram?

High/Low Frequency Pair

Sc1 = High / Sc2 = Low

Everyone has Sc3 (null)

Scianna

- unknown clinical significance

- everyone has null

- resistant to enzymes & chemicals

Dombrock: Why not on antigram?

- poor immunogens

- weakly reactive

- disappear quickly

Dombrock

- high frequency

- has null

- some HTR, no HDN

- resist enzymes, sensitive to DTT

Colton: Why not on antigram?

High/Low Frequency Pair

Coa = High / Cob = Low

Co3 (null) = high

Gerbich

- variable clinical significance

- leach type (null) formed in Papua New Guinea & Melanesia

- clinical elliptocytosis

Gerbich: Why not on antigram?

Variable clinical significance

Ge1 = Low / Ge 2-4 = High

Cromer: Why not on antigram?

- no HDN

- some HTR

Knops: Why not on antigram?

High/Low Frequency Pairs & not clinically significant

Kna = high / Knb = low

McCa = high / McCb = low

Sla/Vil = high

Indian: Why not on antigram?

- High/Low Frequency Pair

- More prevalent in Iran & India

- non-clinical HDN

Ina = low / Inb = high

OK: Why not on antigram?

Non-immunogenic

OK/OKa

- high frequency

- receptor for P. falciparum

- resist enzymes & chemicals

- probable HDN/HTR

- non-immunogenic

RAPH: MER2

- abundant on platelets, reduced in mature RBCs

- high frequency

- HTR

JMH

- clinically insignificant

- HTLA

- Antibodies present in elderly

VEL

- high frequency

- activates compliment

- causes severe hemolysis & HDN

- resist enzymes & chemicals

Jra

- high frequency

- common in Japan

- severe HDN

- multi-drug resistance in tumor cells

Sda

- clinically insignificant

- Tamm-Horsfall glycoprotein in urine

- naturally occurring room temp antibody

AnWJ

- high frequency

- Haemophilus Influenza receptor

- autoantibody

- negative found in Israeli women

HLA: Bga, Bgb, Bgc

- resistant to enzymes & DTT

- neutralized by platelet concentrate

- No HDN

- some HTR