Rheumatological Diseases Lecture Practice

A set of practice flashcards covering various rheumatological conditions including RA, SLE, Gout, and Vasculitis based on lecture transcript notes.

What is the correct rule when prescribing a NSAID for rheumatic diseases to avoid adverse reactions?

It must be prescribed in a minimally efficient dose and duration.

Which medication is used for the symptomatic treatment of psoriatic arthritis?

NSAIDS

Psoriatic arthritis is the rheumatic disease that typically presents with what specific type of arthritis?

Arthritis mutilans

The CASPAR diagnostic criteria are used for the diagnosis of which condition?

Psoriatic arthritis

Which condition is characterized by osteolytic lesions of phalanges and the aspect of “telescoped” fingers?

Psoriatic arthritis

How is axial involvement in psoriatic arthritis characterized?

Unilateral or asymmetric sacroiliitis

How can psoriatic onichodystrophy manifest?

Pitting (punctiform erosion)

Which criterion is NOT used for the diagnosis of psoriatic arthritis?

Positive anti-CCP antibodies

Which classes of NSAIDs are recommended for patients with psoriatic arthritis?

Coxibs and Oxicams

In psoriatic arthritis, which pharmacological management is considered obligatory?

Immune suppressive treatment

What are the characteristic extra-articular manifestations of psoriatic arthritis?

AA amyloidosis, anterior uveitis, and IgA nephropathy

What are the most frequent complications of NSAIDs and glucocorticoid hormone treatment?

Hemorrhage from the upper gastrointestinal tract and gastroduodenal ulcer perforations

Phalangeal involvement in psoriatic arthritis can include which specific signs?

“Sausage finger”, “telescoped fingers”, and “pencil-in-cup fingers”

What are the distinguishing X-ray signs for psoriatic arthritis?

Bone ankylosis, relative crosscut of metacarpophalangeal joints, relative crosscut of metatarsophalangeal joints, and tendency to oligoarticular distribution

Which diseases are associated with the presence of HLA-B27?

Reactive arthritis, ankylosing spondylitis, and psoriatic arthritis

What is considered the “gold standard” of DMARD treatment in rheumatoid arthritis?

Methotrexate

Which joint area is usually affected in rheumatoid arthritis, specifically at the cervical level?

The atlanto-axial joint

What is the False statement regarding extra-articular involvements in rheumatoid arthritis?

They appear before joint involvement.

What respiratory tract involvement can manifest in rheumatoid arthritis?

Pleurisy

What is the major genetic factor associated with rheumatoid arthritis?

HLA DR4

How is the female to male ratio described in rheumatoid arthritis by the age of $70$?

The number of females equals the number of males.

What are the most important proofs of autoimmunity in rheumatoid arthritis?

Rheumatoid factor and anti-cyclic-citrullinated-peptide antibodies

What is the most frequent extra-joint manifestation in reactive arthritis?

Acute anterior uveitis

Which immune-genetic marker plays an important role in the pathogenesis of reactive arthritis?

HLA-B27

What is the purpose of the Schöber test?

It is a method of assessment of lumbar column mobility.

What is the etiological treatment used in reactive arthritis?

Antibiotics

What Shigella species is most frequently responsible for reactive arthritis?

Shigella flexneri

What is the most frequent form of joint involvement in reactive arthritis?

Asymmetric oligoarticular

What are the typical complications of long-standing reactive arthritis?

Chronic keratoconjunctivitis, “cauda equina” syndrome, and aortic valve insufficiency

What is the specific morphological abnormality found in acute rheumatic fever?

Aschoff nodules

What is the typical duration of the latent period in acute rheumatic fever?

$2-4$ weeks

What age group is most frequently affected by acute rheumatic fever?

$7-15$ years

What is the duration of arthritis in acute rheumatic fever?

$2-3$ weeks

Which first-line antibacterial drugs are used in the treatment of acute rheumatic fever?

Penicillins

Pathogenic properties of Group A hemolytic streptococcus in ARF are primarily due to what membrane component?

Protein M

What joint is most often affected in gout?

The I Metatarsophalangeal joint

Which specific renal complication is associated with gout?

Nephrolithiasis

What are the most common sites for gouty nodules, also known as tophi?

Elbows and ears

What uric acid values define hyperuricemia in men and women respectively?

$0.49$ mmol / L for men and $0.39$ mmol / L in women

What heart valve is most frequently affected in systemic lupus erythematosus?

The mitral valve

Which specific variant of lupus nephritis carries the worst prognosis?

Diffuse sclerotic ($>90$% sclerotic glomeruli) lupus nephritis

What are the marker antibodies for systemic lupus erythematosus?

Anti-dsDNA and anti-Sm antibodies

What is the least toxic drug used in systemic lupus erythematosus?

Hydroxychloroquine

What is the clinical manifestation of renal involvement in systemic sclerosis?

Malignant arterial hypertension

The presence of anti-U1RNP antibodies in Mixed Connective Tissue Disease is associated with what prognosis?

Relatively good prognosis for organ involvement

Where are Bouchard nodules localized in osteoarthritis?

Proximal interphalangeal joints

How long does morning stiffness typically last in osteoarthritis?

$5-30$ minutes

What is the daily requirement of Vitamin D for a person older than $50$ years?

$800$ IU

Which vasculitis belongs to the group of large size vessel vasculitides?

Takayasu arteritis

Which viral infection is frequently found in patients with polyarteritis nodosa?

HBV – infection