ARB/Neprilysin inhibitor

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Last updated 9:57 PM on 9/13/26
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9 Terms

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ARB/Neprilysin inhibitor drug

Sacubitril/Valsartan (Entresto)

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indication of ARB/Neprilysin inhibitor

Heart failure with reduced ejection fraction

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mechanism of ARB

Selective, reversible competitive antagonist of angiotensin II receptor which is responsible for vasoconstriction, aldosterone secretion, sympathetic outflow, and simulation of renal sodium reabsorption

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mechanism of Neprilysin inhibitor

inhibits neprilysin leading to decrease breakdown of
natriuretic peptides; inducing vasodilation and natriuresis

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contraindications of ARB/Neprilysin inhibitor

Pregnancy, use of an ACEI within 36 hours

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black box warning ARB/Neprilysin inhibitor

Pregnancy

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ADR common of ARB/Neprilysin inhibitor

Hyperkalemia, hypotension, acute kidney injury

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ADR rare of ARB/Neprilysin inhibitor

Angioedema

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counseling point ARB/Neprilysin inhibitor

drug is for heart failure which can cause dizziness (worse when dehydrated), avoid in pregnancy, use K supplements under medical supervision