Hypersensitivity Reactions fill in

These flashcards cover key concepts related to hypersensitivity reactions, their types, mechanisms, and examples.

Hypersensitivity is characterized by an __ reaction to a specific antigen after a secondary exposure.

overreaction

Type I hypersensitivity includes classic allergic reactions such as __ and asthma.

hayfever

The Hygiene Hypothesis suggests that __ exposure to germs and higher standards of cleanliness may increase allergy rates.

reduced

The IgE specific for the allergen becomes bound to local __ and basophils upon initial exposure.

mast cells

Degranulation involves calcium influx, fall in intracellular cyclic AMP, migration of granules to cell surface, and __ of granules.

exocytosis

Preformed mediators in allergic responses include histamine, which causes vasodilatation and __ muscle constriction.

bronchial

Erythroblastosis fetalis can occur if an Rh- mother has a pregnancy with an Rh+ baby due to the mother’s immune system recognizing the __ factor.

rhesus

In Type II hypersensitivity, transfusion reactions are caused by antibodies against red cell surface __ in the recipient’s serum.

antigens

In Type III hypersensitivity, immune complexes that are not cleared can lead to conditions such as serum sickness or an __ reaction.

Arthus

Type IV hypersensitivity is primarily mediated by a subset of T cells known as __ cells.

T delayed hypersensitivity (TD or TDTH)