Chapter 15: Potential Therapies

Small molecule drug candidates

Small molecule drug candidates

________ can be tested using high- throughput screening.

Viruses

________ may be able to carry therapeutic genes into the brain to correct central nervous system diseases.

NGF

________ (Nerve Growth Factor): a trophic factor that slows the destruction of neurons that use acetylcholine.

Procedures

________ can be developed to modify trophic factor- regulated functions in ways that might be useful in the treatment of neurological disorders.

Antibodies

________ can be engineered to modify the interactions and toxicity of misfolded proteins.

Lasers

________ are used to measure whether proteins are clumped inside cells that have been distributed into containers with small molecules.

inhibit growth

Neutralizing molecules that stop or ________ can help repair damaged nerve fiber tracts in the spinal cord.

Fruit

________ flies that have been modified to carry a mutant gene for Huntingtons are generally too weak & uncoordinated to break out of their pupal case.

Oligodendrocytes

Glial cells that surround axons and make the myelin sheath.

Nogo

________- A: a protein that inhibits nerve regeneration.

potency of the agent

The ________ can be determined by how well it attaches to the receptor /protein target in a test tube.

RNAi

Interfering RNAs.

NGF (Nerve Growth Factor)

A trophic factor that slows the destruction of neurons that use acetylcholine.

Nogo-A

A protein that inhibits nerve regeneration.

Astrocytes

Glial cells that protect and nourish neurons.