DNA Structure and Replication (1)

Flashcards covering key vocabulary terms and concepts related to DNA discovery, structure, and replication.

Miescher

Isolated “nuclein” from soiled bandages in 1869.

Garrod

Studied Protein s & inborn errors in 1902.

Sutton

Studied Chrom osome structure in 1903.

Morgan

Studied Gene mapping in 1913.

Griffith’s Experiment

Discovered Transf orming Principle in 1928.

Chargaff

Studied Base pairing & species specific in 1947.

Hershey and Chase

Conducted experiments in 1952 that helped confirm DNA as genetic material

Friedrich Miescher

Analyzed pus cells from discarded surgical bandages and discovered “nuclein” = nucleic acid

Chargaff's Rule

States that A always pairs with T and C always pairs with G.

Viruses

Showed that genes are made of DNA

Alfred Hershey & Martha Chase (1952)

Infected Escherchia coli (E. coli) = Host cell and Used Radioactive Isotopes: (S35) Sulfur-35 (P32) Phosphorus-32

Why did Hershey & Chase use Sulfur-35 and Phosphorus-32?

Sulfur is found in proteins and not in DNA. Phosphorus is found in DNA but not in protein

Maurice Wilkins and Rosalind Franklin

Worked to discover the 3-D structure of DNA.

James Watson and Francis Crick

In 1953 published a one-page paper in Nature “Molecular Structure of Nuclei Acids: Deoxynucleic Acids”

Rosalind Franklin's Image

Photo 51

Title

DNA Structure and Replication

DNA Replication

Experiments Identify and Describe the Genetic Material