IP 7 Epilepsy Medications Generation and MOA
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22 Terms
Carbamazepine
1st - decreases VGNa+
Clonazepam
1st - PAM at GABAa
lorazepam
1st - PAM at GABAa
diazepam
1ste - PAM at GABAa
midazolam
1st - PAM at GABAa
phenobarbital
1st - PAM at GABAa
phenytoin
1st - decreasesVGNa+
valproate
1st - increases GABA avability and decreases VGNa+ and decreases T-type Ca2+
felbamate
2nd - NMDA antagonist
gabapentin
2nd - decreases Ca2+ channels at alpha2gamma subunit
lamotrigine
2nd - decreases VGNa+ glutamate release
levetriacetam
2nd - decreases symaptic vesicle SV2a protein
oxcarbazepine
2nd - decreases VGNa+
tiagbine
2nd - decreases GAT1 (GABA re-uptake)
topiramate
2nd - decreases VGNa+ and GABAa PAM and decreases carbonic anhydrase hydration and decreases GluR
zonisamide
2nd - decreases VGNa+ and decreases t-type Ca2+
brivaracetam
3rd - decreases SV2a proein
cenobamate
3rd - decreases VGNa+ and PAM GABAa
lacosamide
3rd - decreases VGNA+
perampanel
3rd - decreases GluR
pregabalin
3rd - decreases Ca2+ channels a alpha2gamma subunit
ethosuximide
1st - decreases T-type Ca2+