Part 16: Tests and Disorders for Secondary Hemostasis

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35 Terms

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X-linked recessive

All deficiencies of coagulation factors are transmitted autosomal recessive with the exceptions for Factor VIII deficiency and Factor IX deficiency, which are transmitted as

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340, 000 daltons

Molecular weight of Fibrinogen

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100 to 150 hours

Half-life of Fibrinogen

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200 to 400 mg/dL

Mean Plasma Concentration of Fibrinogen

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Fibrinogen

Most concentrated of all plasma procoagulants

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prolonged

If fibrinogen level is <100 mg/dL, PT and APTT will be ______

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10 mg/dL per decade

Fibrinogen increases approximately _______ in the elderly

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71, 600 daltons

Molecular weight of Prothrombin

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44, 000 daltons

Molecular weight of Tissue Factor

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40 daltons

Molecular weight of Factor IV

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330, 000 daltons

Molecular weight of Factor V and Factor VIII

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50, 000 daltons

Molecular weight of Factor VII

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600, 000 TO 20, 000, 000 daltons

Molecular weight of vWF

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57, 000 daltons

Molecular weight of Factor IX

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58, 800 daltons

Molecular weight of Factor X

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143, 000 daltons

Molecular weight of Factor XI

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84, 000 daltons

Molecular weight of Factor XII

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320, 000 daltons

Molecular weight of Factor XIII

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85, 000 daltons

Molecular weight of Prekallekrein

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120, 000 daltons

Molecular weight of HMWK

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Factor V Leiden

Mutant factor V

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Factor VII

First coagulation factor to be affected by Warfarin therapy

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Factor VII

Has the shortest hal-life

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Liver

Prothrombin is considered as ______ function test

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Factor VII deficiency, the PT

What factor becomes deficient early in liver disease and what assay does its deficiency prolong?

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Factor VIII

Hemophilia A or Classic Hemophilia

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vWF

Largest molecule in the human plasma

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Factor IX

Hemophilia B or Christmas Disease factor

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PTA

PTA or PTC Factor XI

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Factor XI

Hemophilia C or Rosenthal Syndrome

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Factor XI

Factor seen in Ashkenazi Jews

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Factor XII

Factor that has no bleeding tendency but has thrombotic tendency

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5M Urea Clot Solubility Test (Duckert’s Test)

To detect factor XIII deficiency, one may use the _______

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Factor XIII

Not important in clot formation but rather in clot stabilization

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HMWK

aka Flaujeac Factor