CHAPTER 30: ERYTHROCYTIC PROTECTION FROM O2 TOXICITY

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Red blood cells that carry oxygen from the lungs to tissues and transport carbon dioxide from tissues to the lungs.

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10 Terms

1

Red blood cells that carry oxygen from the lungs to tissues and transport carbon dioxide from tissues to the lungs.

Erythrocytes

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2

A protein in erythrocytes that contributes to the red color and gas-carrying capacity. It constitutes about one-third of the weight of a mature erythrocyte.

Hemoglobin

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3

A protein hormone produced by vascular endothelial cells of the kidney that stimulates the production of new red blood cells in the bone marrow.

Erythropoietin (EPO)

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4

The harmful effects of breathing 100% oxygen for several hours, which can cause damage to the lungs, brain, and retina.

Oxygen Toxicity

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5

A highly reactive product derived from oxygen that has a short half-life and can cause tissue damage. It is generated by various processes, including the action of ionizing radiation and the combination of oxygen with hemoglobin.

Superoxide Anion

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6

A highly reactive and toxic product derived from hydrogen peroxide. It affects proteins, DNA, and cell membrane phospholipids, leading to membrane damage and inhibition of metabolic processes.

Hydroxyl Radical

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7

A tripeptide present at high concentrations in erythrocytes that acts as a free radical scavenger and protects against hydrogen peroxide. It contains a sulfhydryl group contributed by cysteine and is constantly being oxidized and reduced to protect against oxidizing agents.

Glutathione

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8

An inactive form of hemoglobin in which the iron has been oxidized from the ferrous to ferric state. It causes a dusky discoloration of the skin and impairs the ability of hemoglobin to carry oxygen.

Methemoglobin

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9

Large rigid structures formed in erythrocytes when the sulfhydryl groups of hemoglobin become oxidized. They can lead to hemolytic anemia and are associated with certain toxins and conditions.

Heinz Bodies

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10

Substances, such as vitamin E and vitamin C, that help protect against oxidative stress and reduce the harmful effects of free radicals in the body.

Antioxidants

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