UW PHYS Wk2
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21 Terms
current
net movement of charge
voltage
how charged something is
conductance (G)
how easily ions can cross the membrane (inverse of resistance)
capacitance
number of charges needed to move to change potential
equilibrium potential
membrane potential at which no net ION movement occurs (for given ion)
reversal potential for ion channel
membrane potential at which no net CHARGE movement occurs
POTASSIUM: Equilibrium Potential
-97 mV
SODIUM: Equilibrium Potential
65 mV
CALCIUM: Equilibrium Potential
127 mV
CHLORIDE: Equilibrium Potential
-71 mV
activated by Gs
adenylyl cyclase
inhibited by Gi or Go
adenylyl cyclase
activated by Gq
phospholipase C (PLC)
cleaved by phospholipase C (PLC)
PIP2 (phosphatidyl inositol bisphosphate)
products of PIP2 cleavage
diacylglycerol and inositol trisphosphate (DAG and IP3)
role of inositol trisphosphate (IP3)
binds to IP3 receptor at ER and opens Ca2+ channel
role of diacylglycerol (DAG)
activates protein kinase C (PKC)
role of cyclic AMP (cAMP)
activates protein kinase A
role of phosphodiesterase
cleaves cAMP back to AMP
steps to desensitize GPCR
GRK phosphorylates receptor, arrestin binds GPCR-P, protein is endocytosed