Reversible Cell Injury II

fatty degeneration, fatty infiltration and steatosis

Fatty change is also called…

Fatty change

This condition is caused by accumulation of fat in non-fatty cells

1. Excessive mobilization of fat

2. Failure of fat metabolism

3. Failure of protein

4. Toxic and metabolic influences

What causes steatosis?

okie dokie yo

Study the diagram that describes one of the cause of fatty change—increased fat mobilization

enlarged organ, greasy tissue; pale, off color

Gross lesion of fatty change

clear vacuoles of fat globules in cytoplasm, sometimes coalescing and displacing nuclei

fatty change under light microscopy

vacuoles of fat globules in cytoplasm

Fatty change under electron microscope

• sudan III — orange red

• osmic acid — black

Special stain used to visualize lesions of Fatty change

Foie gras; Fatty change

what is this? what type of cellular injury is this?

acute cellular swelling

histological image of what cellular injury?

Fatty change

histological image of what cellular injury?

hyaline change

This is a condition caused by accumulation of proteinaceous materials on the cytoplasm of cells

homogenous, glasslike

Various histological or cytological alterations of hyaline change are characterized by ____________ appearance in hematoxylin and eosin-stained sections

intracellular hyaline and extracellular hyaline

what are the types of hyaline change?

damaged blood vessel wall

example of extracellular hyaline

kidney tubular epithelia

example of intracellular hyaline

hyaline change

This is a histological section of what cellular injury?

amyloidosis

this type of condition is chracterized by extracellular fibrilla protein (amyloid) deposited in a variety of tissues

immunoglobulin light chains

Amyloid is derived from __________, usually of lambda type

abnormal clones of Ig secreting plasma cells

the monoclonal ig light chains in amyloidosis are being produced by…

1. serum amyloid a (SAA)

2. AL amyloid (ALA)

3. Transmissible amyloid

4. Hereditary amyloidosis

What are the forms of amyloidosis?

SAA

this form of amyloidosis is caused by misfolding of the major acute-phase protein

ALA

this form of amyloidosis is caused by the misfolding of Ig light chains

ALA

this form of amyloidosis is rare in domestic animals

BSE, Scrapie

example of transmissible amyloid

TA

this form of amyloidosis is caused by the misfolding of prion proteins

HA

this form of amyloidosis is genetic and is reported in Abyssinian cats

1. primary

2. secondary

Forms of Amyloidosis based on cause

Primary Amyloidosis

Forms of Amyloidosis based on of unknown cause, and deposition is from the disease itself