Discuss the uptake of cholesterol via LDL particles through receptor-mediated endocytosis

Discuss the uptake of cholesterol via LDL particles through receptor-mediated endocytosis. Part 1

LDL particles bind to the LDL receptor in the plasma membrane of the cell.

Discuss the uptake of cholesterol via LDL particles through receptor-mediated endocytosis. Part 2

Once the LDL receptor reaches and area of a clathrin-coated pit, it will bind to adaptin proteins

Discuss the uptake of cholesterol via LDL particles through receptor-mediated endocytosis. Part 3

Then any bound LDL and receptor are taken in with the clathrin-coated vesicle

Discuss the uptake of cholesterol via LDL particles through receptor-mediated endocytosis. Part 4

This vesicle is uncoated and fuses with the endosome.

Discuss the uptake of cholesterol via LDL particles through receptor-mediated endocytosis. Part 5

In the low pH of the endosome, the LDL receptor dissociates and is returned to the plasma membrane.

Discuss the uptake of cholesterol via LDL particles through receptor-mediated endocytosis. Part 6

The endosome fuses with a lysosome where the LDL is broken down and the cholesterol released into cytosol to be used by the cell.