Sterile and NonSterile Compounding

What is sterile compounding used for?

Medications injected or infused into sterile body spaces

What is USP

Standards for sterile compounding

What environment is required for sterile compounding?

ISO Class 5 hood in cleanroom

What is the purpose of a laminar airflow hood?

Provide clean air to protect sterile products

What is the first step of aseptic technique?

Handwashing for at least 30 seconds

Correct order of PPE?

Shoe covers → Hair cover → Mask → Gown → Gloves

What disinfectant is used in sterile compounding?

70% isopropyl alcohol

What is TPN?

Total Parenteral Nutrition – IV nutrition

What is USP

Standards for non-sterile compounding

Examples of non-sterile dosage forms?

Creams, ointments, capsules, oral suspensions

What equipment is most accurate for liquids?

Graduated cylinder

What is a Class A prescription balance used for?

Measuring small ingredient amounts in compounding

What is BUD?

Beyond-use date – time a compound is considered safe and stable

BUD for non-aqueous compounds?

6 months or earliest ingredient expiration

BUD for aqueous oral compounds?

14 days (refrigerated)

BUD for aqueous topical compounds?

30 days (room temperature)

Why is BUD different from expiration date?

BUD is based on preparation date and storage method

What is the preferred compounding surface disinfectant?

70% isopropyl alcohol

What is geometric dilution?

Technique to mix ingredients evenly by gradually adding in a diluent

What is levigation?

Reducing particle size using a liquid to make a smooth paste

What is trituration?

Grinding powder into finer particles

What is spatulation?

Mixing powders using a spatula on a flat surface