GI Top 300: Quiz #2

What is the brand for Metoclopramide?

• Reglan

• Gimoti

What is the drug class for Metoclopramide?

Dopamine Antagonist

What are the dosage forms for Metoclopramide?

• Tablet

• ODT

• Oral solution

What are the on-label uses for Metoclopramide?

• Diabetic gastroparesis

• GERD

What are the off-label uses for Metoclopramide?

• Decreased lactation

• Nondiabetic gastroparesis

• Nausea and vomiting caused by chemotherapy, pregnancy, radiation, medical conditions

What is the MOA for Metoclopramide?

• Blocks dopamine D2 receptors

• Sensitizes GI tissue to acetylcholine

• Increases gastric contractions and GI motility

• Accelerates gastric emptying and intestinal transit

What is the boxed warning for Metoclopramide?

Tardive dyskinesia

What are the contraindications for Metoclopramide?

• Hypersensitivity

• GI hemorrhage

• Mechanical obstruction

• Perforation

• Pheochromocytoma

• Concomitant use with drugs likely to cause extrapyramidal reactions

• Epilepsy

Is Metoclopramide safe for pregnancy/lactation?

Pregnancy: compatible

Lactation: compatible

What are the adverse effects for Metoclopramide?

Asthenia, somnolence

What is the brand for Sucralfate?

Carafate

What is the drug class for Sucralfate?

Gastrointestinal Agent, Miscellaneous

What are the dosage forms for Sucralfate?

• Tablet

• Oral Suspension

What are the on-label uses for Sucralfate?

Duodenal Ulcer

What are the off-label uses for Sucralfate?

GERD during pregnanc

What is the MOA for Sucralfate?

• Forms a complex with positively charged proteins that forms a protective coating

• Locally protects the gastric lining against peptic acid, pepsin, and bile salts

What are the boxed warnings for Sucralfate?

None

What are the contraindications for Sucralfate?

Hypersensitivity

Is Sucralfate safe for pregnancy/lactation?

Pregnancy: Compatible

Lactation: Probably compatible

What are the adverse effects for Sucralfate?

None