Complex Lipids Part 3

What is Type I Hyperlipoproteinemia?

Familial hyperchylomicronemia

What is Type IIA Hyperlipoproteinemia?

Familial hypercholesterolemia

What is Type IIB Hyperlipoproteinemia?

Combined hyperlipidemia

What is Type III Hyperlipoproteinemia?

Familial dysbetalipoproteinemia

What is Type IV Hyperlipoproteinemia?

Familial hypertriglyceridemia

What is Type V Hyperlipoproteinemia?

Combined hypertriglyceridemia

LDL variant found in patients with obstructive jaundice and LCAT deficiency

LpX Lipoprotein

Same density as LDL and same size as VLDL but no Apo B

LpX Lipoprotein

Abnormal lipoprotein that accumulates in type 3 hyperlipoproteinemia and hepatic lipase deficiency

ẞ-VLDL Lipoprotein / Floating ẞ Lipoprotein

IDL with defective Apo E

ẞ-VLDL Lipoprotein / Floating ẞ Lipoprotein

Are abnormalities marked by decreased lipoprotein concentrations

HYPOLIPOPROTEINEMIA

– HDL concentrations as low as 1-2 mg/dL (0.03 – 0.05 mmol/L)

– Higher prevalence of CHD and stroke

Hypoalphalipoproteinemia

Defective Apo-A1

Familial Hypoalphalipoproteinemia

Defective ABCA1 transporter

Tangier Disease

Complete LCAT deficiency

Familial LCAT Deficiency

Partial LCAT deficiency

Fish Eye Disease

Low levels of LDL-cholesterol due to decreased production of Apo B-100

Hypobetalipoproteinemia

Decreased TAG export from liver = ?

FATTY LIVER DISEASE

Defect in microsomal triglyceride transfer protein (MTP)

Abetalipoproteinemia