Oc Pharm 1 (Dry Eye Disease Treatments)

Which medication is an anti-inflammatory treatment for dry eye?

Eysuvis (loteprednol etabonate 0.25%)

What class of medication is Eysuvis (loteprednol etabonate 0.25%)?

corticosteroid

What must be monitored in a patient using a corticosteroid?

IOP

What technology does Eysuvis (loteprednol etabonate 0.25%) use to enhance ocular surface tissue distribution?

aMMPlify (mucopartical penetrating)

Which medications can increase the concentration of anti-inflammatory mediators within the tear film?

Cyclosporine analogs

What are examples of Cyclosporine analogs?

Restasis, Cequa, Vevye

What is the composition of Restasis?

cyclosporine 0.05% emulsion

What is the composition of Cequa?

cyclosporine 0.09% solution

What is the composition of Vevye?

cyclosporine 0.1% solution

What is the MOA of Cyclosporin analogs?

calcineurin inhibitor (inhibits IL2 production)

Which medications are used in the presence of keratoconjunctivitis sicca?

Restasis and Cequa

What technology does Cequa (cyclosporin 0.09%) use to improve penetration into the T-cell?

nanomicellar

What technology does Vevye (cyclosporin 0.1%) use to increase the absorption into the cornea?

perfluorobutylpentane

How long does it take for Cyclosporin analogs to inhibit T-cell activation?

~90 days

Which Cyclosporin analog doesn't require a preservative since there is no water in the drug/vehicle?

Vevye

Which medication is a common LFA-1 antagonist used in the treatment of dry eye disease?

Xiidra (lifitegrast 5% oph sol)

What is a side effect specifically associated with Xiidra (lifitegrast 5% oph sol)?

Dyguesia (bad taste)

What is the MOA of Autologous Serum eye drops for the treatment of dry eye disease?

increase concentration of anti-inflammatory properties in the tears

What is a demulcent?

water soluble polymer

What is a emollient?

usually a fat or oil (applies to eyelids)

What is the most commonly used cellulose derived demulcent?

Carboxymethycellulose sodium

What are the most commonly used emollients?

Lanolin and Oleaginous

Which medication is used intranasally to increase lacrimation in patients with dry eye disease?

Tyrvaya (varenicline sol 0.03mg)

What is the MOA of Tyrvaya (varenicline sol 0.03mg)?

activation of CN V parasympathetic pathway via the nose

Which medication stimulates the thermoreceptors which activate CN V signaling for basal tear production in dry eye patients?

Tryptyr (acoltremon 0.003% oph sol)

What are the two types of punctal plugs?

punctal occlusion and intracanalicular

Which punctal plugs are intracanalicular?

Lacrifill

How long do intracanalicular punctal plugs last?

6 mo

What is the difference between temporary and permanent punctal plugs?

temporary dissolve and permanent don't

Which OTC medications are used to decrease tear film evaporation?

Miebo, oral doxycycline, lid hygiene products, Xdemvy

What is the composition of Miebo?

100% drug no water in vehicle

What is the MOA of Doxycycline?

30s ribosome inhibitor

What is an ADR associated with Doxcycline?

photosensitivity

What is the MOA of Xdemvy?

GABA chloride channel inhibitor resulting in mite paralysis

What are side effects of Xdemvy use?

chalazia/hordeola formation, punctate keratitis

What are therapeutic levels of Omega-3 Fatty Acid supplementation for dry eye disease?

2000 mg/day of EPA/DHA

What is a caution when using Omega-3 Fatty Acid supplementation?

blood thinner

Which Omega-3 Fatty Acid supplementation form is best absorbed?

Triglyceride EPA/DHA

1 multiple choice option