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these serve as a barrier to microbes from the interior of the body
epidermidis, epithelial cells lining the GI tract, reproductive tract, urinary tract, & respiratory tract
tight junctions with adjacent cells
prohibit anything, including small molecules from passing between cells
goblet cells
produce mucins; “fly paper” that traps microbes
movement including peristalsis and cilia
flushes “trapped” microbes out of the animal
stomach acid
can be a formidable barrier for microbe to traverse on its way to the intestine