Development of B Lymphocytes (13)

What is the pathway of B cell development in primary lymphoid organs?

Stem cell, Pre-B cell, Immature B cell (IgM+), and Mature B cell (IgM+ , IgD+)

What are the outcomes of B cell development in secondary lymphoid organs?

IgM, IgG, Memory B cell, IgA, and IgE

What occurs to allow mature B cells to develop into IgG, Memory B cells, IgA, and IgE?

Isotype switching and somatic mutations

B cell development in primary lymphoid organs is?

Antigen independent

B cell development in secondary lymphoid organs is?

Antigen-dependent

Immature B cells undergo selection process to become [blank]

self-tolerant

Multivalent self-antigen undergo apoptosis after what?

Clonal deletion

Soluble self-antigen IgM migrate to periphery to become?

Anergic B cells

No self-reaction with IgM migrate to the periphery to become?

Self-tolerant mature B cells

Describe the circulation of naive B cells in lymph nodes

Blood vessels, HEV, T-cell area, B-cell area, primary lymphoid follicle, T cell area, medullary cords, efferent lymphatic vessel

What are the two types of antigens for B-cell stimulation?

Thymus-dependent (TD) antigens and Thymus-independent (TI) antigens

-Need T-cell help for activation of B cells and production of antibodies

-Usually are protein or glycoprotein antigens

Thymus-dependent (TD) antigens

-Can induce antibody production in the absence of T-cell help

-Usually these are bacterial capsular polysaccharides with highly repetitive structures or B-cell mitogens such as LPS

Thymus-independent (TI) antigens

Effect of specific antigen on B cell migration and differentiation