WBC - Not Complete but will work (hopefully)

• Neutrophil

• Eosinophil

• Basophil

GRANULOCYTES

• Lymphocyte

• Monocyte

AGRANULOCYTES

Neutrophil

have phagocytic activity against bacteria and other small particles

Myeloperoxidase with Superoxide

form a powerful killing system

Eosinophil

An increase in the number associated with allergic reaction and parasitic infection

basophil

These cells play an important role in the allergy and hypersensitivit

Histamine and Heparin

Basophil granules contain mainly _______ and _________

Monocytes

The nucleus is horseshoe- or kidney-shaped

Monocytes

Migrate into the tissues and develop into macrophages

Monocytes

The main function is phagocytosis but also has ability to secret certain substances like interleukins

Macrophage

Have important functions in inflammation and immunity

Macrophage

These are tissue monocytes

lymphocytes

• B Lymphocytes

• T Lymphocytes

• Natural Killer Cell

All types of _________ are related to immune reactions in defending against invading microorganisms, foreign macromolecules, and cancer cells.

T LYMPHOCYTES

LYMPHOCYTES

• Represents 60-80% of circulating lymphocytes in the peripheral blood

• Matures at the thymus

• End products of activation are CYTOKINE

B LYMPHOCYTES

LYMPHOCYTES

• Represents 20-35% of lymphocytes population

• Matures at bone marrow

• Precursors cells in antibody production

• Are the precursor of plasma cell

NATURAL KILLER CELLS

• Represents 10-15% of total lymphocytes population

• They are under the NATURAL IMMUNITY, thus they are non specific compared to B and T cells

• They are essential mediators of virus immunity

• They can destroy virally infected cells or tumor cell

WBC Elevated

WBC ELEVATED or DROP

Bacterial Infections, Leukemia, Appendicitis, Pregnancy, HDN, Ulcer

WBC DROP

WBC ELEVATED or DROP

Viral Infection (Measles) , brucellosis, typhoid fever, infectious hepatitis, rheumatoid arthritis, cirrhosis of the liver and SLE

Myeloblast

GRANULOCYTE PRECURSOR

First recognizable stage in bone marrow

Promyelocytes

GRANULOCYTE PRECURSOR

• Appearance of PRIMARY GRANULES (Non-Specific)

• Has Paranuclear halo or hof

Myelocyte

GRANULOCYTE PRECURSORS

• Secondary Granules (Specific)

• Last stage of mitosis

• DAWN OF NEUTROPHILIA

• Youngest cell a granulocyte can be identified

METAMYELOCYTES

GRANULOCYTES PRECURSORS

• Indented, Kidney, Peanut Shape nucleus

• FIRST STAGE FOR SYNTHESIS OF TERTIARY/GELATINASE GRANULES

  • Predominant Cell in the bone marrow

BAND CELLS

GRANULOCYTE PRECURSOR

• Curved or Sausage Shaped

• Youngest cell in the series present in peripheral blood

• FIRST IMMATURE WBC to be released in the circulation

  • SECRETORY GRANULES begin to form

NULL LYMPHOCYES/ NK cell

3rd populati