Campbell Biology in Focus Chapter 6

metabolism

the totality of an organism's chemical reactions, consisting of catabolic and anabolic pathways, which manage the material and energy resources of the organism

metabolic pathway

a series of chemical reactions that either builds a complex molecule (anabolic pathway) or breaks down a complex molecule into simpler compounds (catabolic pathway)

catabolic pathway

a metabolic pathway that releases energy by breaking down complex molecules to simpler compounds

anabolic pathway

a metabolic pathway that consumes energy to synthesize a complex molecule from simpler compounds

bioenergetics

(1) the overall flow and transformation of energy in an organism; (2) the study of how energy flows through organisms

energy

the capacity to cause change, especially to do work (to move matter against an opposing force)

kinetic energy

the energy associated with the relative motion of objects; moving matter can perform work by imparting motion to other matter

heat (thermal energy)

the total amount of kinetic energy due to the random motion of atoms or molecules in a body of matter; also called thermal energy; heat is energy in its most random form

potential energy

the energy that matter possesses as a result of its location or spatial arrangement (structure)

thermodynamics

the study of energy transformations that occur in a collection of matter

first law of thermodynamics

the principle of conservation of energy: energy can be transferred and transformed, but it cannot be created or destroyed

entropy

a measure of disorder, or randomness

second law of thermodynamics

the principle stating that every energy transfer or transformation increases the entropy of the universe; ordered forms of energy are at least partly converted to heat

free energy

the portion of a biological system's energy that can perform work when temperature and pressure are uniform throughout the system; (the change in free energy of a system is calculated by the equation δg = δh

exergonic reaction

a spontaneous chemical reaction, in which there is a net release of free energy

endergonic reaction

a nonspontaneous chemical reaction, in which free energy is absorbed from the surroundings

polyphosphorylated

referring to a molecule that is covalently bonded to a phosphate group

enzyme

a macromolecule serving as a catalyst, a chemical agent that changes the rate of a reaction without being consumed by the reaction

catalyst

a chemical agent that increases the rate of a reaction without being consumed by the reaction

substrate

the reactant on which an enzyme works

enzyme

substrate complex

active site

the specific portion of an enzyme that binds the substrate by means of multiple weak interactions and that forms the pocket in which catalysis occurs

cofactor

any nonprotein molecule or ion that is required for the proper functioning of an enzyme; cofactors can be permanently bound to the active site or may bind loosely with the substrate during catalysis

coenzyme

an organic molecule serving as a cofactor; most vitamins function as coenzymes in metabolic reactions

competitive inhibitor

a substance that reduces the activity of an enzyme by entering the active site in place of the substrate whose structure it mimics

noncompetitive inhibitor

a substance that reduces the activity of an enzyme by binding to a location remote from the active site, changing the enzyme's shape so that the active site no longer functions effectively

allosteric regulation

the binding of a regulatory molecule to a protein at one site that affects the function of the protein at a different site

cooperativity

a kind of allosteric regulation whereby a shape change in one subunit of a protein caused by substrate binding is transmitted to all the others, facilitating binding of subsequent substrate molecules

feedback inhibition

a method of metabolic control in which the end product of a metabolic pathway acts as an inhibitor of an enzyme within that pathway