11. Extracellular Matrix & Mineralization

What are the components of the bone extracellular matrix?

Protein fibers and minerals

What are the two components of the extracellular matrix of bone?

Organic matrix (osteoid) and inorganic matrix

What percentage of bone mass does the organic matrix make up?

35% of bone mass

What is the organic matrix mostly made of?

Mostly collagen fibers

What forces does the organic matrix resist?

Resists pulling and twisting forces

What percentage of bone mass does the inorganic matrix make up?

65% of bone mass

What bone mineral forms from calcium hydroxide and calcium phosphate?

Hydroxyapatite

What is the mineral of bone?

Hydroxyapatite

What does the inorganic matrix store?

Calcium and phosphorous

What is calcification?

Minerals deposit around protein fibers

Where does calcification happen?

In inorganic matrix

What function does calcification provide to bone?

Make bone strong and able to resist compression

What effect does removing the organic matrix (collagen) have on bone?

Makes bones very brittle

What effect does removing the inorganic matrix (mineral) have on bone?

Makes bones very soft