Anti inflammatory drugs

Anti inflammatory & pain relief drugs

Block actions of prostglandins (Cox Pathway)

Prostaglandins

Mediates inflammation, sensitizes nerve ending to nociceptive chemical mediators, mediates fever

Why do we give NSAIDS

Block effects of prostaglandins

Salicylates

aspirin

Aspirin MOA

Non-specific inhibition of cyclooxygenase pathway resulting in diminished prostaglandin production

Apsirin indications

Treatment of mild to moderate pain, fever,

numerous inflammatory conditions

NSAIDS

ibuprofen, naproxen, diclofenac

Ibuprofen MOA

Non-specific inhibition of cyclooxygenase

pathway resulting in diminished prostaglandin production (decreased platelet aggregation-reversible/transient,

Ibuprofen indications

mild to moderate pain, fever reduction, dysmenorrhea

Ibuprofen interactions

Decreases anti-platelet effects of aspirin

Selective Cyclooxygenase-2 inhibitor

Celecoxib

Celecoxib MOA

selectively blocks COX-II enzymes---> reduce prostglandins

Non-NSAID analgesics

Acetaminophen (tylenol)

Acetaminophen MOA

non-opiod & non-NSAID analgesic effect, has no anti-inflammatory effect