pharm finls aghhh pt1

Aminoglycosides MOA?

binds to ribosome

Aminoglycosides effective for? and why?

aerobic cuz enters through oxygen pump

Amikacin brand?

Amikan

Gentamicin brand?

Garasone

Tobramycin brand?

Tobrax

Aminoglycoside causes?

wrong translation of mRNA

Aminoglycoside ADV

ototoxic (ear) and nephrotoxic (kidney)

Aminoglycoside bacteria resistant by?

extra functional group (-acetyl / -phophoryl)

Aminoglycoside used for?

severe infections

Amikacin, Gentamicin, Tobramycin which group?

Aminoglycoside

Cephalosporin MOA?

binds to PBP

Cephalosporin 1st gen use?

(+) aerobic on skin

Cephalosporin 2nd gen use?

(+) and (-)

Cephalosporin 3rd gen use?

(-) anaerobic in organs

Cefazolin brand?

Ancef

Cephalexin brand?

Keflex

Cefaclor brand?

Ceclor

Cefuxomine brand?

Ceftin

Ceftazidime brand?

Fortaz

Ceftriaxone brand?

Rocephin

Cefixime brand?

Suprax

Cefepime brand?

Maxipime

Cephalosporin causes?

cross-linking of peptidoglycan

Cephalosporin ADV

diarrhea, nausea

Cephalosporin bacteria resistant by?

b-lactam destroying enzyme

Cephalosporin NOT used for?

infectious diarrhea

Cefazolin, Cephalexin, Cefaclor which group?

Cephalosporin

Floroquinolone MOA?

stops gyrase

Floroquinolone contraindicated for?

pregnant and children less than 16 yrs

Floroquinolone why not allowed for pregnant and children?

cartilage malformations

Ciproflaxacin brand?

Cipro

Gatifloxacin brand?

Zymar

Levofloxacin brand?

Levaquin

Moxifloxacin brand?

Avelox

Ofloxacin brand?

Ocuflox

Floroquinolone causes?

no transcription

Floroquinolone NOT ADV

ototoxic

Floroquinolone warning? why?

no Fe, Zn, and Ca cuz drug binds to it = no absorption

Floroquinolone used for?

broad-spectrum

Ciprofloxacin, Gatifloxacin, Ofloxacin which group?

Floroquinolone

Macrolide MOA?

binds to ribosome

Macrolide fridge?

yes

Macrolide causes?

can’t connect amino acid to polypeptide

Macrolide NOT ADV

nausea

Macrolide bacteria NOT resistant by?

b-lactam destroying enzyme

Macrolide NOT used for?

meningitis

Macrolide which for H. pylori?

Clarithromycin

Azithromycin, Clarithromycin, Erythromycin which group?

Macrolide

Azithromycin brand?

Zithromax

Clarithromycin brand?

Biaxin

Erythromycin brand?

Ery “___”

Macrolide drug-drug interaction?

weakens contraceptives

Oxazolidinone MOA?

binds to ribosome

Oxazolidinone effective on?

(+) pneumonia and skin

Oxazolidinone causes?

stops a setp of protein translation

Oxazolidinone ADV why?

high blood pressure cuz it’s a MAOI = too much NE

Linezolid brand?

Zyvoxan

Linezolid which group?

Oxazolidinone

Penicillin MOA?

binds to PBP

Penicillin used for?

broad-spectrum

Penicillin causes?

stops cross-linking of peptidoglycan

Penicillin NOT ADV

arrythmia

Penicillin bacteria resistant by?

b-lactam destroying enzyme

If allergic to Penicillin, also allergic to?

Cephalosporin

Tazobatam, clavicular acid used for?

b-lactamase breakdown

Penicillin VK brand?

Pen Vee

Amoxicillin + Clavicular acid brand?

Clavulin

Pipera + Tazobatam brand?

Tazocin

Pipera which group?

Penicillin

“True antiinfective” mean?

naturally-occuring

Penicillin from?

bread and fruit mold

Carbapenem similar most to?

Penicillin

Carbapenem vs. Penicillin?

Carbapenem resitant to b-lactamase

Menpenum brand?

Merrem

Menpenum which group?

Carbapenem

Sulfonomide MOA?

stops folic acid production

Sulfonomide used for?

AIDS-pneumonia

Sulfamethoxazole + Timethoprim brand?

Septra

Sulfonomide ADV

crystalluria, photosensitive

Tetracycline MOA?

binds to ribosome

Tetracycline causes?

stops tRNA binding

Tetracycline used for?

broad-spectrum

Tetracycline used for acne?

yes

Tetracycline NOT ADV

stomach upset

Tetracycline warning?

no Ca, Al, Fe

Tetracycline contraindicated for? why?

no pregnant and children cuz weakens bone growth

Doxycyline, Minocycline which group?

Tetracycline

Doxycycline brand?

Vibramycin

Minocycline brand?

Minocin

MISC. Izozianid (Nidrazide) MOA?

stops myolic acid synthesis = no cell wall

MISC. Metronidazole (Flagyl) MOA? used for?

amoebacide, giardiasis, Trichoniasis, C.diffile, acne

MISC. Mupirocin (Bactobem) applied by? used for?

by skin, staph skin

MISC. Chloranphenicol MOA? used for?

stops protein synthesis, for meningitis, hair, rocky mt.

MISC. Clindaycin (Clin-___) ADV?

C. diffile infectious diarrhea

MISC. Clindaycin (Clin-___) used for?

acne and vaginosis