Harrold Final Exam General Drug Resistance Mechanisms

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9 Terms

1
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Penicillins and Cephalosporins Bacterial Resistance Mechanisms

Inactivation of drug

Altered binding site

2
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Colistimethate Bacterial Resistance Mechanisms

Altered binding site

Efflux

3
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Sulfonamides Bacterial Resistance Mechanisms

Altered binding site

Efflux

Alternative metabolic pathway to produce either dihydropteroate or folic acid

Increased production/uptake of PABA

4
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Fluoroquinolones Bacterial Resistance Mechanisms

Gene mutations of gyrA and/or gyrB enzymes → altered binding site

5
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Aminoglycoside Bacterial Resistance Mechanisms

Acquisition of genes that inactivate the drug

Alterations in transport into the cell

Altered binding site

Efflux

6
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Tetracycline Bacterial Resistance Mechanisms

Alterations in transport into the cell

Ribosomal protection proteins alter binding of drug to its target

Inactivation of drug

7
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Macrolide Bacterial Resistance Mechanisms

Efflux

Altered binding site

Inactivation of drug

8
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Chloramphenicol Bacterial Resistance Mechanisms

Inactivation of drug

9
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Oxazolidinones (-zolid) Bacterial Resistance Mechanisms

Altered binding site caused by mutations in chromosomal genes for L3 and L4