W2 --> Intro to Blood banking/ Blood group

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9 Terms

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What are the components of blood?

1) RBC

2) Plasma

3) Platelets

4) Cryoprecipitate

5) Granulocytes

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What are the routine testing done on blood?

  • ABO/Rh typing

  • Antibody screening

  • Antibody indentification

  • Crossmatch

  • DAT

  • Cord Blood testing

  • Prenatal/Postpartum

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What is blood group system?

1 or more antigens produced by alleles at a single gene locus or loci

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What is collections?

Antigens that do not meet the criteria for a system

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Where is the blood group genes locate?

Autosomal chromosomes

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What is a null phenotype?

A paired chromosome that carry same silent gene

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How are Blood group antigen defined?

Defined by their biochemical structures

  • aka carbohydrates, proteins and glycoproteins

  • polymorphics

  • high prevalenst vs low prevalent

  • containing antigenic determinants

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What is polyclonal?

Antibodies are directed against all the epitopes of one antigenWh

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What is Monoclonal antibody?

Hybridoma technology

  • highly specific and uniformly reactive