Antigen-Antibody Interactions

• Antigen

  • Immunogen = induce immune response

• Refers to thesubstance that react with antibody or sensitized T cell

• It is not able to trigger an immune response on its own

• Immunogen

• Refers to the substance that is capable of induding an immune response on its own

• All immunogen are antigen, but not all antigen are immunogen

• All _______ are _______, but not all ______ are immunogen

• Autoantigen

TYPE OF ANTIGEN:

• Antigen of the same individual

• Alloantigen

TYPE OF ANTIGEN:

• Antigen of different individuals but the same spp

• Heteroantigen

TYPE OF ANTIGEN:

• Antigen of two different spp

• Heterophile Antigen

TYPE OF ANTIGEN:

• Antigens in unrelated plants or animals but are identical or closely related in structure

• Epitope = antigen

• Paratope = antibody

• Epitope is found in _______

• Paratope is found in _______

• Haptens

• A substance that requires carrier molecule to elicit immune response (turns to immunogen)

• Example: Therapeutic Drugs

• Adjuvants

• A substance that is added to increase and itensify immune response (e.g vaccines)

• Papain

• What enzyme causes breakdown of antibodies above the hinge region

• [ 2 Fab + Fc = 3 fragments]

• Pepsin

• What enzyme causes breakdwon of antibodies below the hinge region

• [ F(ab’)2 + Fc’ ]

• Isotype

ANTIBODIES VARIATION:

• Variation in the constant region of heavy chain

• specifies what type of Ig class

• [Heavy Chain: gamma, mu, alpha, epsilon, delta]

• Allotype

ANTIBODIES VARIATION:

• Variation of constant region of light and heavy chain

• specifies the subclasses of each immonoglobulin

• Idiotype

ANTIBODIES VARIATION:

• Variation of variabe region of light and heavy chain

• determine why antibodies are specific to an antigen

• IgG

CLASSES OF IMMUNOGLOBULINS:

• most abundant in serum

• IgG

CLASSES OF IMMUNOGLOBULINS:

• for inflammation

• IgG

CLASSES OF IMMUNOGLOBULINS:

• participate in Complement Fixation

• IgG 1

• IgG 3

• IgG 4

IgG 2 = can’t cross placenta

CLASSES OF IMMUNOGLOBULINS:

• Subclasses of Immunoglobulins that passes through placenta (in order)

• IgG 3

• IgG 1

• IgG 2

IgG 4 = can’t

CLASSES OF IMMUNOGLOBULINS:

• Subclasses of Immunoglobulins that participates in complement fixation (in order)

• IgM

CLASSES OF IMMUNOGLOBULINS:

• pentamer

• IgM

CLASSES OF IMMUNOGLOBULINS:

• Most primitive

• 1st form in babies

• IgM

CLASSES OF IMMUNOGLOBULINS:

• found only in blood vessels

• IgA 2 = resistant

• IgD = susceptible

CLASSES OF IMMUNOGLOBULINS:

1. most resistant to proteolysis

2. most susceptible to proteolysis

• IgD

CLASSES OF IMMUNOGLOBULINS:

• anti-idiopathic antibody

• IgE

CLASSES OF IMMUNOGLOBULINS:

• Reagenic

• Participates in allergic reaction

• Lag = longer

• Log = increase

• Plateau = short

• Rapid decline

Describe the kinetic of PRIMARY immune response

• Lag = shorter

• Log = sudden decrease

• Plateau = longer

• Gradual decline

Describe the kinetic of Secondary immune response