HCl Efflux by Parietal Cells
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4 Terms
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Where are parietal cells located?
In the gastric glands of the stomach lining.
2
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How do parietal cells secrete HCl?
The H⁺/K⁺ ATPase pump exchanges intracellular H⁺ for extracellular K⁺ at the apical membrane.
3
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What role does carbonic anhydrase play?
It produces H⁺ and HCO₃⁻ from CO₂ and water to fuel acid secretion.
4
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How is bicarbonate handled during HCl secretion?
It is exchanged for Cl⁻ at the basolateral membrane, leading to Cl⁻ entering the lumen and forming HCl with secreted H⁺.
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