chapter 26 - nonmalignant leukocyte disorders

Pelger-Huet anomaly

inherited leukocyte disorder caused by mutation in the lamin B receptor

May-Hegglin anomaly

inherited leukocyte disorder involving mutations in nonmuscle myosin heavy chain IIA

Alder-Reilly anomaly

morphologic leukocyte abnormality that is a common manifestation of the mucopolysaccharidoses

Gaucher disease

lysosomal storage disease characterized by macrophages with striated cytoplasm & storage of glucocerebroside

all of the above

neutrophils in chronic granulomatous disease are incapable of producing

• hydrogen peroxide

• hypochlorous acid

• superoxide

• all of the above

IL-2 receptor

individuals with X-linked SCID have a mutation that affects their ability to synthesize

viral infection

absolute lymphocytosis with reactive lymphocytes suggests

Dohle bodies

leukocyte cytoplasmic inclusion composed of ribosomal RNA

high total WBC count with slight shift to the left in neutrophils

expected CBC results for women in active labor include

reactive lymphocytes have increased cytoplasm with variable basophilia

true about absolute increase in lymphocytes with reactive morphology

• population of lymphocytes appears morphologically homogenous

• are usually effector B cells

• reactive lymphocytes have increased cytoplasm with variable basophilia

• most commonly seen in bacterial infections