BME 101: Tissue/Imaging Quiz

part 1: tissue

ECM

gives mechanical & chemical signaling support; aka scaffold

local environment…

changes cells

cells change…

the local environment

scaffolds

natural or synthetic materials

metal scaffold pros

mechanical strength and conductivity

metall scaffold cons

loss of flexibility

metal scaffold example

titanium (does not degrade over time/stays in body forever)

degradable metal scaffolds

magnesium/iron

ceramic scaffolds pros

mechanical stability

ceramic scaffold example

cavities

ceramic scaffolds cons

very brittle

polymer(plastic) scaffolds pros

versatile, easy to manufacture

polymer scaffolds cons

mechanical properties are not great

cells with scaffolds

MSC, iPSC, Embryonic

Mesenchymal Stem Cells

most highly used; produced by long bone mesenchymal

cells MSC can turn into

bone, cartilage, fat, muscle, neural

MSC cons

don’t work well as we age

Induced Pluripotent Stem Cells

cells can turn into most cell types

iPSC cons

have tumorigenic capabilities

Embryonic Stem Cells pros

can differentiate into any cell type

Embryonic Stem Cells cons

illegal to use in the entire world

Endogenous Stem Cells

cells that are residents in your body

Exogenous Stem Cells

cells that are added to your body from the outside

Bioactive factors

components that cause a bioreaction (growth factors, cytokines)

bioactive factors pros

less risk of rejection compared to using cells for scaffolds

bioactive factors cons

cannot be done for a long period of time, unlike cells