CNS Tumors

glial, nerve

tumors arise more often from ______ vs ______ due to ongoing replication

headaches, seizures, changes in cognitive function

common first symptoms of cancer

metastatic (lung and breast most)

most common cause of brain and spinal column cancer

likelihood of becoming worse and ending in death

metastasis

Grades I, II, III, IV; how abnormal cells look

how is brain cancer stages

cytological malignancy

likelihood that cancer will kill based on cell morphology

biological malignancy

liklihood that cancer will kill based on tumor location (may be benign)

Gliomas, Meningiomas, Pituitary adenomas, schwannoma

types of primary tumors by histological classifications

polio virus, CBS, CAR-T cells

research based immunotherapy

Tentorium

70% of childhood cancers are below the _____

early morning headache, nausea, vomiting, ataxic gait, incoordination, lathargy

classic signs of infra-tentorial cancers

astrocytoma

cytologically benign, slow growing, good prognosis unless in brainstem. Most common childhood cancer often in cerebellum

medulloblastoma

• cerebellar PNET

• highly malignant and metastacizes to subarachnoid space

• poor outcomes

• second most common childhood cancer

ependymoma

• cancer in ventricles, difficult to resect

• third most common childhood cancer

tentorium

70% of adult cancers are above the

headaches, seizuresm personality and cognitive changes

supratentorial cancer symptoms

Meningioma

• most common primary tumor

• seizures from compression of cortex not invding tissue

• highly vascular

• easy to surgicially remove

Glioma (Glioblastoma multiform-astrocytoma (GBM-A)

• very cytologically malignant (50% of all)

• highly malignant, 18 months or less

• frequently in frontal or temporal lobe

• not all are as aggressive

pituitary tumor

• usually anterior and benign

• secreting or non-secreting

• may compress the 3rd ventricle, brain stem, optic chiasm

• peripheral vision may be impacted