Other Motor Drugs

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7 Terms

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D2 Antagonists / Haloperidol

Most effective for tics & decrease DA overactivity

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SSRIs / Fluoxetine/Sertraline/Clomipramine

treat OCD symptoms

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Botulinum Toxin (TS)

focal/disabling tics

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Botulinum Toxin (dystonia)

Act at NMJ

Inhibits ACh exocytosis by cleaving SNARE proteins (SNAP-25, VAMP, syntaxin) → chemical denervation

Treatment of choice for focal dystonia

Resistance due to antibodyformation

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Baclofen

act at SC

GABA-B agonist → presynaptic inhibition

Intrathecal in severe dystonia

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Anticholinergics

Act at CNS & NMJ

Muscarinic receptor antagonists

First-line adults (Children: L-DOPA first)

Lose efficacy = circuitadaptation

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Benzodiazepines

Act at CNS

GABA-A agonists

Less effective; sedation