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Intradermal (gauge)
26 or 27
Subcutaneous (gauge)
25 to 27
Intramuscular (gauge)
18 to 23
Intradermal (needle size)
3/8 to 5/8 inches
Subcutaneous (needle size)
1/2 to 5/8 inches
Intramuscular (needle size)
1 to 3 inches
Intradermal (angle)
10° to 15°
Subcutaneous (angle)
45°
Intramuscular (angle)
90°
Intradermal (volume)
Less than 1 mL
Subcutaenous (volume)
0.5, 1.0, 2.0 mL
Intramuscular (volume)
Up to 3.0 mL
Intradermal (injection site)
Any skin surface, hairless, with little friction from clothes; ex: upper chest, scapular areas of the back, and inner forearms
Subcutaneous (injection sites)
Fatty layer of tissue just below the skin, rotate sites to prevent irritation; ex: abdomen (at least 2 inches away from the belly button), back of the upper arms, and outer thighs
Intramuscular (injection sites)
Bulky muscle regions; ex: deltoid, vastus lateralis, rectus femoris, and ventral gluteal