Testicular Tumors Pathology Flashcards

Vocabulary flashcards covering the classification, clinical features, gross morphology, and microscopic pathology of testicular tumors.

Seminomatous Tumors

A category of testicular germ cell tumors that includes seminoma and spermatocytic seminoma.

Non-seminomatous Tumors

A classification of testicular germ cell tumors that includes embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.

Sex Cord-Stromal Tumors

A category of testicular tumors that includes Leydig cell tumor, Sertoli cell tumor, and Granulosa cell tumor.

Seminoma

The most frequent testicular cancer, occurring predominantly in the 3rd decade of life, with the greatest association with cryptorchid testes; it is identical to dysgerminoma of the ovary.

Seminoma Spread

Dissemination of seminoma occurring via lymphatics to retroperitoneal, mediastinal, and supraclavicular lymph nodes, and hematogeneously to the lungs.

Seminoma Gross Morphology

Bulky tumor with a homogeneous, gray-white, lobulated cut surface that is devoid of hemorrhage or necrosis.

Seminoma Microscopic Histology

Sheets of uniform cells with abundant clear cytoplasm, sharply outlined cell membranes, large central nuclei, and prominent nucleoli, divided into poorly demarcated lobules by septa of fibrous tissue containing lymphocytes.

Embryonal Carcinoma

A non-seminomatous germ cell tumor usually occurring in the 20-30 years age group, commonly mixed with other germ cell tumors, and more aggressive than seminomas.

Embryonal Carcinoma Gross Morphology

A bulky, variegated tumor showing areas of hemorrhage and necrosis on cut section.

Embryonal Carcinoma Microscopic Histology

Histologically arranged in an alveolar or tubular pattern or in sheets, consisting of anaplastic cells with hyperchromatic nuclei and prominent nucleoli.

Teratoma

A testicular germ cell tumor affecting males of all ages, containing tissue derivatives from ectoderm, endoderm, and mesoderm.

Teratoma Gross Morphology

Predominantly cystic and multiloculated tumor where foci of cartilage and bone may be present.

Teratoma Microscopic Features

Microscopic presentation consisting of neural tissue, muscle bundles, islands of cartilage, squamous epithelium, and structures reminiscent of thyroid gland, bronchial epithelium, intestinal wall, or brain substance embedded in fibrous or myxoid stroma.

Immature Teratoma

A teratoma that presents with tissue immaturity, such as the presence of primitive glands.