tpice 7 pd: selectivity and drug responsiveness

what is selectivity in drug effect? (2)

most drugs are selective

only binds to certain receptors

what happens to less selective drugs? (2)

more side effects higher drug response

binds to all forms of receptor within the drug

what are the variations in drug responsiveness? (5)

age

genetic factors

disease

tolerance

drug drug interactions

drug drug interactions - inducers (5)

drug a metabolised by cyp450 enzymes

drug b induced cyp450 enzymes

increases metabolism of drug a

lowering plasma concentration of drug a

results in sub-therapeutic effect of drug a

drug drug interaction: inhibitors (5)

drug c metabolised by cyp450 enzymes

drug d inhibits cyp450 enzymes

decreases metabolism of drug c

increasing plasma concentration of drug c

results in a toxicity effect of drug c

how does tolerance occur?

occurs during prolong exposure to an agonist or antagonist