'ceutics is my new best friend <3 - pH med chem

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Last updated 3:21 PM on 9/25/26

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17 Terms

1

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Alcohols

pKa 16-19

ALWAYS UNIONIZED AT pH 2 OR 7.4

2

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Carboxylic acid

pKa 5

Ionized at pH 7.4

Unionized at pH 2

3

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Amine

pKa 10

Ionized at both pH 7.4 and 2

4

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<p>Phenol</p>

Phenol

pKa 9-11

Weak acid - unionized at pH 7.2 and 2

5

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<p>Sulfonamide</p>

Sulfonamide

pKa 9-10

Weak acid - unionized at pH 7.2 and 2

6

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<p>Imide</p>

Imide

pKa 9-10

Weak acid- unionized at pH 7.2 and 2

7

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<p>Alkylthiol</p>

Alkylthiol

pKa 10-11

Weak acid - unionized at pH 7.2 and 2

8

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<p>Thiophenol</p>

Thiophenol

pKa 9-10

Weak acid - unionized at pH 7.2 and 2

9

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<p>N-arylsulfonamide</p>

N-arylsulfonamide

pKA 6-7 ;)

Weak acid

Unionized at pH 2

Ionized at pH 7.4

10

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<p>sulfonimide</p>

sulfonimide

pKa 5-6

Weak acid

Unionized at pH 2

Ionized at pH 7.4

11

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<p>Alkylcarboxylic acid</p>

Alkylcarboxylic acid

pKa 5-6

Weak acid

Unionized at pH 2

Ionized at pH 7.4

12

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<p>arylcarboxylic acid</p>

arylcarboxylic acid

pKa 4-5

Unionized at pH 2

Ionized at pH 7.4

13

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<p>Sulfonic acid</p>

Sulfonic acid

Weak acid

pKa 0-1

Ionized at pH 2 and 7.4

14

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<p>aniline</p>

aniline

Weak base

pKa 4.6

ionized at pH 2

Unionized at pH 7.4

15

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<p>alkylamines</p>

alkylamines

pKa 10-11 if secondary

pKa 9-10 if primary

Ionized at pH 2 and 7.4

16

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<p>Amidine</p>

Amidine

pKa 10-11

Ionized at pH 2 and 7.4

17

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<p>Guanidine</p>

Guanidine

pKa 12-13

Ionized at pH 2 and 7.4