ch 4 comparison of Hodgkins lymphoma and non-Hodgkins lymphoma

Hodgkin lymphoma

large multinucleated Reed-Sternberg cells in lymph nodes

lymph nodes are destroyed by increased growth of monocytes and macrophages

extranodal involvement is rare

disease is local

more common in white individuals than in african american individuals

non-hodgkin lymphoma NHL

proliferation of malignant lymphocytes

many subtypes including large b-cell lymphoma and Burkitt lymphoma

extranodal involvment is common

disease is disseminated in its extent

Hodgkin lymphoma cause

unknown

infection with Epstein-Barr virus

genetic tendency

contact with environmental and occupational toxins

NHL causes

unknown

chromosomal translocations

infections

environmental factors

immunodeficiency states AIDS

patients who have had chemotherapy or radiation

hodgkin lymphoma clinical manifestations

slow and subtle onset

lymph node enlargement

weight loss

fever

fatigue

weakness

chills

tachycardia

night sweats

NHL clinical manifestations

develop slowly or rapidly

painless enlarged lymph node

hodgkin lymphoma diagnostic testing

biopsy of lymph tissue - presence of Reed-Sternberg cells

radiologic studies- determine which lymph nodes are involved

NHL diagnostic testing

biopsy of lymph node- identify cell type

MRI and CT scan- visualize other organ involvement

hodgkin lymphoma treatment

can be asymptomatic

chemotherapy

radiation

treatments to alleviate symptoms and protect from infection

NHL treatment

chemotherapy

immunotherapy

radiation