Drugs: timing and notes

Onset time of propofol

30-60 sec

Duration of propofol

10-15 min

Onset time of thiopental

20-30 sec

Duration of thiopental

10-15 min

Dosages of propofol

Full dose = 4 mg/kg

Give 1 mg/kg at a time

Contraindications for propofol

• Hemodynamically unstable

• Pancreatitis (lipid emulsion form)

• Repeated use/CRI in cats

Contraindications for thiopental

• Greyhounds

• Hemodynamically unstable

• CRI usage

Onset time of etomidate

60 sec

Duration of etomidate

10-20 min

Contraindications for etomidate

• Adrenal insufficiency

• CRI usage

Onset time of alfaxalone

60 sec

Duration of alfaxalone

10 min

Contraindications for alfaxalone

• Hemodynamically unstable

• Large animals? due to large volumes needed

Onset time of ketamine

IM: 5-10 min

IV: 60-90 sec

Duration of ketamine

30-45 min

Contraindications for ketamine

• HCM or critically ill

• Head trauma

• C sections

• Cats with kidney disease (reduce dose)

Onset time of tilazol (tiletamine + zolazepam)

IM: 5-10 min

IV: 60-90 sec

Duration of tilazol (tiletamine + zolazepam)

30-60 min

Contraindications for tilazol (tiletamine + zolazepam)

• Head trauma

• HCM

• Critically ill

• Multiple dosages needed (leads to rough recoveries)